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用于光动力疗法的多功能卟啉排列——综述

Versatile Porphyrin Arrangements for Photodynamic Therapy-A Review.

作者信息

Glowacka-Sobotta Arleta, Czarczynska-Goslinska Beata, Ziental Daniel, Wysocki Marcin, Michalak Maciej, Güzel Emre, Sobotta Lukasz

机构信息

Chair and Department of Orthodontics and Temporomandibular Disorders, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.

Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.

出版信息

Nanomaterials (Basel). 2024 Nov 22;14(23):1879. doi: 10.3390/nano14231879.

DOI:10.3390/nano14231879
PMID:39683268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643599/
Abstract

Nanotechnology is an emerging field that involves the development of nanoscale particles, their fabrication methods, and potential applications. From nanosized inorganic particles to biopolymers, the variety of nanoparticles is unstoppably growing, offering huge opportunities for drug delivery. Various nanoformulations, such as nanoparticles, nanocomposites, and nanoemulsions, have been developed to enhance drug stability, solubility, and tissue penetration. Moreover, nanocarriers can be specifically engineered to target diseased cells or release the drug in a controllable manner, minimizing damage to surrounding healthy tissues and reducing side effects. This review focuses on the combinations between porphyrin derivatives and nanocarriers applied in photodynamic therapy (PDT). PDT has emerged as a significant advance in medicine, offering a low-invasive method for managing infections, the treatment of tumors, and various dermatoses. The therapy relies on the activation of a photosensitizer by light, which results in the generation of reactive oxygen species. Despite their favorable properties, porphyrins reveal non-specific distribution within the body. Nanotechnology has the capability to enhance the PS delivery and its activation. This review explores the potential improvements that are provided by the use of nanotechnology in the PDT field.

摘要

纳米技术是一个新兴领域，涉及纳米级粒子的开发、其制造方法及潜在应用。从纳米尺寸的无机粒子到生物聚合物，纳米粒子的种类在不断增加，为药物递送提供了巨大机遇。已开发出各种纳米制剂，如纳米粒子、纳米复合材料和纳米乳液，以提高药物稳定性、溶解度和组织穿透性。此外，纳米载体可经过特殊设计以靶向病变细胞或以可控方式释放药物，从而将对周围健康组织的损害降至最低并减少副作用。本综述聚焦于卟啉衍生物与应用于光动力疗法（PDT）的纳米载体之间的组合。光动力疗法已成为医学领域的一项重大进展，为控制感染、治疗肿瘤及各种皮肤病提供了一种微创方法。该疗法依赖于光对光敏剂的激活，进而产生活性氧。尽管卟啉具有良好特性，但它们在体内会呈现非特异性分布。纳米技术有能力增强光敏剂的递送及其激活。本综述探讨了在光动力疗法领域使用纳米技术所带来的潜在改进。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/11643599/927b8b913c64/nanomaterials-14-01879-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6ba/11643599/f609a63d6b9b/nanomaterials-14-01879-g012.jpg
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