Maeda S, Sachs L
J Cell Physiol. 1978 Feb;94(2):181-5. doi: 10.1002/jcp.1040940207.
There are clones of myeloid leukemic cells that can be induced to differentiate by the normal differentiation-inducing protein MGI to form Fc and C3 rosettes, mature macrophages and granulocytes. One of these clones (MGI+DMSO+) was also inducible by dimethylsulfoxide (DMSO) for C3 but not Fc rosettes, and for mature macrophages but not for mature granulocytes. Other clones (MGI+DMSO-) were inducible by MGI but not DMSO and a third type of clone (MGI-DMSO-) was not inducible by either compound. Clones that differed in their inducibility by DMSO showed a similar inhibition of cell multiplication by DMSO. The results indicate, that some stages of differentiation can be induced by DMSO in an appropriate clone of myeloid leukemic cells and that there are different cellular sites for induction by DMSO and MGI.
存在一些髓系白血病细胞克隆，它们可被正常的分化诱导蛋白MGI诱导分化，形成Fc和C3花环、成熟巨噬细胞和粒细胞。其中一个克隆（MGI+DMSO+）也可被二甲基亚砜（DMSO）诱导形成C3花环，但不能形成Fc花环，可诱导形成成熟巨噬细胞，但不能形成成熟粒细胞。其他克隆（MGI+DMSO-）可被MGI诱导，但不能被DMSO诱导，第三种克隆类型（MGI-DMSO-）则不能被这两种化合物诱导。对DMSO诱导性不同的克隆对DMSO抑制细胞增殖表现出相似性。结果表明，在适当的髓系白血病细胞克隆中，DMSO可诱导某些分化阶段，且DMSO和MGI的诱导细胞位点不同。
