Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.
University of Fortaleza, Fortaleza, Brazil.
Nat Prod Res. 2020 Mar;34(5):692-705. doi: 10.1080/14786419.2018.1493588. Epub 2018 Nov 16.
Flavonoids have aroused much interest in research, since they present a great diversity of biological activities observed in vitro, such as: antioxidant effect, modulation of the enzymatic activity and inhibition of cellular proliferation, exerting beneficial effects on the organism, as well as the use of its therapeutic potential. With wide distribution in the plant kingdom represent a class of phenolic compounds that differ in their chemical structure and particular characteristics. The objective of this review was to describe the relevant aspects of flavonoids, reporting the different known groups, the probable mechanisms by which they act, their pharmacological properties and to gain a better understanding of the reported beneficial health effects of these substances. This systematic review consisted of research using scientific databases such as Scopus, Science Direct, PubMed, SciVerse and SciELO, without time limitation. Some pharmacological properties of some flavonoids and their health benefits have been confirmed by previous studies.
类黄酮在研究中引起了极大的兴趣，因为它们在体外表现出多种生物活性，如抗氧化作用、调节酶活性和抑制细胞增殖，对机体有有益的影响，以及利用其治疗潜力。它们在植物界中广泛分布，代表了一类酚类化合物，在化学结构和特殊性质上有所不同。本综述的目的是描述类黄酮的相关方面，报告不同的已知类群、它们作用的可能机制、它们的药理学特性，并更好地了解这些物质所报道的有益健康的影响。本系统综述包括使用科学数据库（如 Scopus、Science Direct、PubMed、SciVerse 和 SciELO）进行的研究，没有时间限制。一些类黄酮的药理学特性及其对健康的益处已被先前的研究证实。
