具有抗菌和药物传递性能的聚（甲基丙烯酸）改性医用棉纱布，可用作伤口敷料。

Poly(methacrylic acid)-modified medical cotton gauzes with antimicrobial and drug delivery properties for their use as wound dressings.

机构信息

Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo # 140, 25294, Saltillo, Coahuila, Mexico.

CONACyT-Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna Hermosillo # 140, 25294, Saltillo, Coahuila, Mexico.

出版信息

Carbohydr Polym. 2019 Feb 1;205:203-210. doi: 10.1016/j.carbpol.2018.10.015. Epub 2018 Oct 9.

DOI:10.1016/j.carbpol.2018.10.015

PMID:30446096

Abstract

Medical cotton gauzes were modified by grafting poly(methacrylic acid) (PMAA) via free radical polymerization to obtain wound dressings with antimicrobial and drug delivery properties. The effect of several reaction parameters including monomer and initiator concentrations, reaction time, and temperature was studied. The grafting was confirmed by Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), swelling studies, and scanning electron microscopy (SEM). The grafted cotton gauzes (gauze-g-PMAA) samples were loaded with ZnO nanoparticles to endow with antibacterial properties. Also, they were tested as drug eluting systems using nalidixic acid as antimicrobial agent. The antibacterial activity of the ZnO-loaded gauze-g-PMAA samples was evaluated against Escherichia coli (E. coli) and Staphylococcus epidermidis (S. epidermidis). The PMAA-grafted gauzes showed antibacterial activity and inhibited the growth of both microorganisms. These results suggest that the PMAA-grafted cotton gauzes could be used in the biomedical area particularly as antimicrobial and drug-eluting wound dressings.

摘要

医用棉纱布通过自由基聚合接枝聚（甲基丙烯酸）（PMAA），得到具有抗菌和药物输送性能的伤口敷料。研究了几种反应参数的影响，包括单体和引发剂浓度、反应时间和温度。接枝通过傅里叶变换红外光谱（FT-IR）、热重分析（TGA）、溶胀研究和扫描电子显微镜（SEM）得到证实。接枝后的棉纱布（纱布-g-PMAA）样品负载 ZnO 纳米粒子，赋予其抗菌性能。此外，它们还被用作载药体系，以萘啶酸作为抗菌剂。负载 ZnO 的纱布-g-PMAA 样品的抗菌活性针对大肠杆菌（E. coli）和表皮葡萄球菌（S. epidermidis）进行了评估。接枝 PMAA 的纱布表现出抗菌活性，并抑制了两种微生物的生长。这些结果表明，接枝 PMAA 的棉纱布可用于生物医学领域，特别是作为抗菌和药物洗脱伤口敷料。