Zhang Bilin, Huang Zhifeng, Guo Tian, Jing Jingchen, Dang Yunzhi
Department of Radiation Oncology, Shaanxi Provincial People's Hospital, Xi'an, 710086, China.
Xi'an Medical University, Xi'an, 710086, China.
Sci Rep. 2025 Jul 1;15(1):22142. doi: 10.1038/s41598-025-09261-y.
Infectious wounds have increasingly become a significant clinical challenge due to their high incidence and suboptimal treatment outcomes. An ideal wound dressing would be a smart, in situ-formed material with exceptional antibacterial properties and the ability to eliminate biofilms, thereby facilitating effective wound closure. Bacterial cellulose (BC) is an attractive candidate for wound healing applications due to its unique characteristics, including high water retention, flexibility, biocompatibility, and substantial adsorption capacity. However, its limited antibacterial activity constrains its use in skin wound healing. In this work, we employed BC as a matrix material, silver nanoparticles (Ag) as antibacterial agents, and granulocyte-macrophage colony-stimulating factor (GM-CSF) as a cell growth-promoting factor to enhance the healing of infected chronic wounds. The resulting BC/Ag/GM-CSF composite demonstrated excellent blood compatibility, cell compatibility, and antibacterial efficacy. Additionally, the BC/Ag/GM-CSF composite film shows promising potential as a wound dressing for both acute and chronic infectious wounds.
由于感染性伤口的高发病率和不理想的治疗效果，它们日益成为一项重大的临床挑战。理想的伤口敷料应是一种智能的原位形成材料，具有卓越的抗菌性能和消除生物膜的能力，从而促进伤口有效愈合。细菌纤维素（BC）因其独特的特性，包括高保水性、柔韧性、生物相容性和强大的吸附能力，是伤口愈合应用中颇具吸引力的候选材料。然而，其有限的抗菌活性限制了它在皮肤伤口愈合中的应用。在这项工作中，我们采用BC作为基质材料，银纳米颗粒（Ag）作为抗菌剂，以及粒细胞巨噬细胞集落刺激因子（GM-CSF）作为细胞生长促进因子，以促进感染性慢性伤口的愈合。所得的BC/Ag/GM-CSF复合材料表现出优异的血液相容性、细胞相容性和抗菌效果。此外，BC/Ag/GM-CSF复合膜作为急性和慢性感染性伤口的伤口敷料显示出有前景的潜力。
