Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China; School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China.
Carbohydr Polym. 2019 Feb 1;205:533-539. doi: 10.1016/j.carbpol.2018.10.095. Epub 2018 Oct 29.
Bacterial biofilms are widely associated with persistent infections and food contamination. High resistance to conventional antimicrobial agents resulted in an urgent need for novel formulation to eliminate these bacterial communities. Herein we fabricated light controllable chitosan micelles loading with thymol (T-TCP) for elimination of biofilm. Due to the exterior chitosan, T-TCP micelles easily bind to negative biofilm through electrostatic interaction and efficiently deliver the essential oil payloads. Under irradiation, T-TCP micelles generated ROS, which triggered simultaneous thymol release and also resulted in additional ROS-inducing bactericidal effects, both effectively eradicating biofilms of Listeria monocytogenes and Staphylococcus aureus. This formulation provided a platform for other water-insoluble antimicrobials and might be used as a potent and controllable solution to biofilm fighting.
细菌生物膜广泛与持续性感染和食物污染有关。由于对传统抗菌剂的高度耐药性，因此迫切需要新的制剂来消除这些细菌群落。在此，我们制备了光控载有百里香酚的壳聚糖胶束（T-TCP）以消除生物膜。由于外部的壳聚糖，T-TCP 胶束可以通过静电相互作用轻松地与负电生物膜结合，并有效地传递精油有效载荷。在光照下，T-TCP 胶束产生 ROS，这引发了百里香酚的同时释放，并且还导致了额外的 ROS 诱导的杀菌作用，两者都有效地消除了单核细胞增生李斯特菌和金黄色葡萄球菌的生物膜。该制剂为其他水溶性抗菌剂提供了一个平台，并且可能被用作一种有效的、可控的生物膜清除解决方案。
