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肥胖患者中初次全膝关节置换术采用骨水泥型假体与非骨水泥型假体的生存分析:至少 5 年随访。

Increased Survivorship of Cementless versus Cemented TKA in the Morbidly Obese. A Minimum 5-Year Follow-Up.

机构信息

Department of Orthopaedic Surgery, University of Louisville, Louisville, KY.

Franciscan Health Total Joint Reconstruction, Carmel, IN.

出版信息

J Arthroplasty. 2019 Feb;34(2):309-314. doi: 10.1016/j.arth.2018.10.016. Epub 2018 Oct 17.

Abstract

BACKGROUND

Total knee arthroplasty (TKA) in the morbidly obese patients can be challenging with an increased risk of complications. Studies have shown increased aseptic failures with well-aligned cemented TKAs in the obese patient. The purpose of this study is to determine if TKA in the morbidly obese (body mass index [BMI] ≥ 40) using cementless implants would demonstrate improved results and survivorship compared to cemented TKA at a minimum 5-year follow-up.

METHODS

This is a retrospective study comparing clinical results of cemented vs cementless primary TKA with a posterior stabilized design TKA in morbidly obese (BMI ≥ 40) patients with minimal 5-year follow-up. There were 108 patients in the cementless group with a mean BMI of 45.6. In the cemented cohort, there were 85 cemented TKAs with a mean BMI of 45.0. Demographic, clinical, surgical, and radiographic data along with complications were extracted for all study patients.

RESULTS

There were 5 failures requiring revision in the cementless group, including 1 for aseptic tibial loosening (0.9%). In the cemented group, there were 22 failures requiring revision, including 16 implants for aseptic loosening (18.8%; P = .0001). Survivorship with aseptic loosening as the endpoint was 99.1% in the cementless group vs 88.2% in the cemented cohort at 8 years (P = .02).

CONCLUSION

Morbidly obese patients (BMI ≥ 40) have a higher failure due to aseptic loosening with cemented TKA with decreasing survivorship over time. The use of cementless TKA in morbidly obese patients with the potential of durable long-term biologic fixation and increased survivorship appears to be a promising alternative to mechanical cement fixation.

摘要

背景

在病态肥胖患者中进行全膝关节置换术(TKA)具有挑战性,并且并发症的风险增加。研究表明,在肥胖患者中,即使使用对线良好的水泥固定 TKA,无菌性失败的风险也会增加。本研究的目的是确定在病态肥胖患者(体重指数[BMI]≥40)中使用非水泥固定植入物进行 TKA 是否会在至少 5 年的随访中显示出更好的结果和存活率。

方法

这是一项回顾性研究,比较了在病态肥胖(BMI≥40)患者中使用后稳定设计的 TKA 进行水泥固定与非水泥固定初次 TKA 的临床结果,随访时间至少为 5 年。非水泥组有 108 例患者,平均 BMI 为 45.6。在水泥组中,有 85 例水泥固定 TKA,平均 BMI 为 45.0。所有研究患者均提取了人口统计学、临床、手术和影像学数据以及并发症。

结果

非水泥组有 5 例需要翻修的失败病例,其中 1 例为无菌性胫骨松动(0.9%)。在水泥组中,有 22 例需要翻修的失败病例,其中 16 例为无菌性松动(18.8%;P=.0001)。以无菌性松动为终点,非水泥组的 8 年存活率为 99.1%,水泥组为 88.2%(P=.02)。

结论

对于水泥固定 TKA,病态肥胖患者(BMI≥40)由于无菌性松动而导致的失败率更高,并且随着时间的推移,存活率逐渐降低。在病态肥胖患者中使用非水泥 TKA 似乎是一种有前途的替代机械水泥固定的方法,因为它具有潜在的长期生物学固定和增加的存活率。

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