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Why did the sham-treated EPISOD study subjects do so well? Important lessons for research and practice.接受假治疗的EPISOD研究对象为何表现如此良好？对研究和实践的重要启示。
Gastrointest Endosc. 2019 May;89(5):1054-1055. doi: 10.1016/j.gie.2018.11.006. Epub 2018 Nov 14.
2
[Endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction after cholecystectomy: the last EPISOD].胆囊切除术后疑似Oddi括约肌功能障碍的内镜括约肌切开术：最后的EPISOD研究
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Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy: results from the EPISOD prospective multicenter randomized sham-controlled study.疑似Oddi 括约肌功能障碍患者行胆管或双括约肌切开术的 ERCP 后胰腺炎的发生率和预测因素：来自 EPISOD 前瞻性多中心随机假对照研究的结果。
Endoscopy. 2015 Oct;47(10):884-90. doi: 10.1055/s-0034-1392418. Epub 2015 Jul 10.
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The EPISOD study: long-term outcomes.EPISOD 研究：长期结局。
Gastrointest Endosc. 2018 Jan;87(1):205-210. doi: 10.1016/j.gie.2017.04.015. Epub 2017 Apr 25.
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Sphincter of Oddi Dysfunction.奥迪括约肌功能障碍
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Post-cholecystectomy syndrome and sphincter of Oddi dysfunction: past, present and future.胆囊切除术后综合征与Oddi括约肌功能障碍：过去、现在与未来
Expert Rev Gastroenterol Hepatol. 2016 Dec;10(12):1359-1372. doi: 10.1080/17474124.2016.1251308. Epub 2016 Nov 2.
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Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial.EPISOD 多中心试验中疑似 Oddi 括约肌功能障碍患者的社会心理特征和疼痛负担。
Am J Gastroenterol. 2014 Mar;109(3):436-42. doi: 10.1038/ajg.2013.467. Epub 2014 Jan 21.
8
Is endoscopic sphincterotomy avoidable in patients with sphincter of Oddi dysfunction?对于患有Oddi括约肌功能障碍的患者，内镜下括约肌切开术是否可以避免？
Eur J Gastroenterol Hepatol. 2008 Jan;20(1):15-21. doi: 10.1097/MEG.0b013e3282eeb4a1.
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Management of Sphincter of Oddi Dysfunction: Teaching an Old SOD New Tricks?Oddi括约肌功能障碍的管理：能否让古老的SOD有新变化？
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Outcomes of Endoscopic Retrograde Cholangiopancreatography (ERCP) and Sphincterotomy for Suspected Sphincter of Oddi Dysfunction (SOD) Post Roux-En-Y Gastric Bypass.内镜逆行胰胆管造影术（ERCP）及括约肌切开术治疗 Roux-en-Y 胃旁路术后疑似Oddi括约肌功能障碍（SOD）的疗效
Obes Surg. 2017 Oct;27(10):2656-2662. doi: 10.1007/s11695-017-2696-4.

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Endoscopic sphincterotomy for adults with biliary sphincter of Oddi dysfunction.成人胆胰管壶腹括约肌功能障碍的内镜下括约肌切开术。
Cochrane Database Syst Rev. 2024 Mar 22;3(3):CD014944. doi: 10.1002/14651858.CD014944.pub2.
2
Controversies on the endoscopic and surgical management of pain in patients with chronic pancreatitis: pros and cons!慢性胰腺炎患者疼痛的内镜治疗与手术治疗的争议：利弊分析！
Gut. 2019 Aug;68(8):1343-1351. doi: 10.1136/gutjnl-2019-318742. Epub 2019 May 25.

本文引用的文献

1
The EPISOD study: long-term outcomes.EPISOD 研究：长期结局。
Gastrointest Endosc. 2018 Jan;87(1):205-210. doi: 10.1016/j.gie.2017.04.015. Epub 2017 Apr 25.
2
Open-label placebo treatment in chronic low back pain: a randomized controlled trial.慢性下腰痛的开放标签安慰剂治疗：一项随机对照试验。
Pain. 2016 Dec;157(12):2766-2772. doi: 10.1097/j.pain.0000000000000700.
3
To what extent are surgery and invasive procedures effective beyond a placebo response? A systematic review with meta-analysis of randomised, sham controlled trials.手术和侵入性操作在超出安慰剂反应的程度上有多大效果？一项对随机、假对照试验进行荟萃分析的系统评价。
BMJ Open. 2015 Dec 11;5(12):e009655. doi: 10.1136/bmjopen-2015-009655.
4
Measuring nonspecific factors in treatment: item banks that assess the healthcare experience and attitudes from the patient's perspective.衡量治疗中的非特异性因素：从患者角度评估医疗保健体验和态度的题库。
Qual Life Res. 2016 Jul;25(7):1625-34. doi: 10.1007/s11136-015-1178-1. Epub 2015 Nov 12.
5
Patient-Provider Interactions Affect Symptoms in Gastroesophageal Reflux Disease: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial.医患互动对胃食管反流病症状的影响：一项初步随机、双盲、安慰剂对照试验
PLoS One. 2015 Sep 30;10(9):e0136855. doi: 10.1371/journal.pone.0136855. eCollection 2015.
6
Placebo Effects in Medicine.医学中的安慰剂效应。
N Engl J Med. 2015 Jul 2;373(1):8-9. doi: 10.1056/NEJMp1504023.
7
Reevaluating the placebo effect in medical practice.重新评估医学实践中的安慰剂效应。
Z Psychol. 2014;222(3):124-127. doi: 10.1027/2151-2604/a000177.
8
Effect of endoscopic sphincterotomy for suspected sphincter of Oddi dysfunction on pain-related disability following cholecystectomy: the EPISOD randomized clinical trial.内镜下括约肌切开术治疗疑似Oddi 括约肌功能障碍对胆囊切除术后疼痛相关残疾的影响：EPISOD 随机临床试验。
JAMA. 2014 May;311(20):2101-9. doi: 10.1001/jama.2014.5220.
9
The placebo response in clinical trials-the current state of play.临床试验中的安慰剂效应——现状。
Complement Ther Med. 2013 Apr;21(2):98-101. doi: 10.1016/j.ctim.2012.12.010. Epub 2013 Jan 18.
10
The placebo effect: advances from different methodological approaches.安慰剂效应：不同方法学途径的进展。
J Neurosci. 2011 Nov 9;31(45):16117-24. doi: 10.1523/JNEUROSCI.4099-11.2011.

Why did the sham-treated EPISOD study subjects do so well? Important lessons for research and practice.

作者信息

Cotton Peter B

机构信息

Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, USA.

出版信息

Gastrointest Endosc. 2019 May;89(5):1054-1055. doi: 10.1016/j.gie.2018.11.006. Epub 2018 Nov 14.

DOI:10.1016/j.gie.2018.11.006
PMID:30447217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6475602/
Abstract
摘要