边缘型人格障碍的神经生物学

The Neurobiology of Borderline Personality Disorder.

作者信息

Perez-Rodriguez Maria Mercedes, Bulbena-Cabré Andrea, Bassir Nia Anahita, Zipursky Gillian, Goodman Marianne, New Antonia S

机构信息

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, New York, NY 10029, USA; Department of Psychiatry, Mental Illness Research Education and Clinical Centers, VA Bronx Health Care System, 130 W Kingsbridge Road, Bronx, NY 10468, USA; Department of Psychiatry and Forensic Medicine, Autonomous University of Barcelona (UAB), Campus de la UAB, Plaça Cívica, 08193 Bellaterra, Barcelona, Spain.

出版信息

Psychiatr Clin North Am. 2018 Dec;41(4):633-650. doi: 10.1016/j.psc.2018.07.012.

DOI:10.1016/j.psc.2018.07.012

PMID:30447729

Abstract

This article reviews the most salient neurobiological information available about borderline personality disorder (BPD) and presents a theoretic model for what lies at the heart of BPD that is grounded in those findings. It reviews the heritability, genetics, and the biological models of BPD, including the neurobiology of affective instability, impaired interoception, oxytocin and opiate models of poor attachment or interpersonal dysfunction, and structural brain imaging over the course of development in BPD; and posits that the core characteristic of BPD may be an impairment in emotional interoception or alexithymia.

摘要

本文回顾了有关边缘型人格障碍（BPD）的最显著的神经生物学信息，并基于这些发现提出了一个关于BPD核心问题的理论模型。它回顾了BPD的遗传率、遗传学和生物学模型，包括情感不稳定的神经生物学、内感受受损、依恋不良或人际功能障碍的催产素和阿片类模型，以及BPD发展过程中的脑结构成像；并假定BPD的核心特征可能是情感内感受或述情障碍受损。