伏隔核深部脑刺激治疗甲基苯丙胺成瘾：两例报告
Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction: Two Case Reports.
作者信息
Ge Shunnan, Chen Yukun, Li Nan, Qu Liang, Li Yang, Jing Jiangpeng, Wang Xin, Wang Jing, Wang Xuelian
机构信息
Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China.
出版信息
World Neurosurg. 2019 Feb;122:512-517. doi: 10.1016/j.wneu.2018.11.056. Epub 2018 Nov 15.
BACKGROUND
Methamphetamine (MA) addiction is one of the most prevalent socioeconomic and health problems worldwide. In recent years, deep brain stimulation (DBS) has increasingly been used for the treatment of addiction.
CASE DESCRIPTION
This study reports on 2 MA-dependent patients who received DBS of the nucleus accumbens (NAc). During the approximately 2-year follow-up period, one patient (A) remained abstinent and presented with positive emotional experiences, whereas the other (B) had no significant psychobehavioral changes during stimulation at low-to-moderate voltages and subsequently relapsed. Through coregistration of preoperative magnetic resonance imaging with postoperative computed tomography/magnetic resonance imaging, the DBS electrode of patient A was confirmed to be accurately implanted in the NAc, whereas one side of the electrode of patient B deviated from the target.
CONCLUSIONS
These case reports demonstrate that NAc-DBS maybe a possible treatment option for MA addiction.
背景
甲基苯丙胺（MA）成瘾是全球最普遍的社会经济和健康问题之一。近年来，深部脑刺激（DBS）越来越多地用于成瘾治疗。
病例描述
本研究报告了2例接受伏隔核（NAc）DBS治疗的MA依赖患者。在大约2年的随访期内，1例患者（A）保持戒断状态并表现出积极的情感体验，而另1例患者（B）在低至中等电压刺激期间无明显心理行为变化，随后复发。通过术前磁共振成像与术后计算机断层扫描/磁共振成像的配准，证实患者A的DBS电极准确植入NAc，而患者B的一侧电极偏离靶点。
结论
这些病例报告表明，NAc-DBS可能是MA成瘾的一种治疗选择。
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