Ting C C
J Natl Cancer Inst. 1978 Feb;60(2):437-44. doi: 10.1093/jnci/60.2.437.
Cytotoxic T (thymus)-lymphocytes (CTL) with specific cytotoxicity against the leukemia-associated antigens of FBL-3, a syngeneic Friend virus-induced leukemia in C57BL/6 mice, could be adoptively transferred to sublethally X-irradiated (350 R) syngeneic hosts and could be induced by adoptive transfer of either normal or presensitized lymphocytes obtained from immunocompetent hosts. The CTL and their precursor cells were systemically distributed in peripheral lymph nodes and spleen, although they had the tendency of homing to the lymphoid tissue of the same origin. Direct cytotoxicity was obtained with the lymphocytes from these lymphoid tissues, and cells obtained from these lymphoid tissues could produce secondary cytotoxic responses by the mixed lymphocyte tumor cell culture reactions 40--60 days after adoptive transfer. In addition, lymph node and spleen cells had a synergistic effect on the induction of cytotoxicity. These findings indicated that tumor immunity was widely distributed and that various populations of lymphocytes were involved in the generation of efficient cell-mediated cytotoxic responses.
对FBL-3白血病相关抗原具有特异性细胞毒性的细胞毒性T（胸腺）淋巴细胞（CTL），FBL-3是C57BL/6小鼠中同基因Friend病毒诱导的白血病，可被过继转移至经亚致死剂量X射线照射（350拉德）的同基因宿主，并且可通过过继转移从免疫活性宿主获得的正常或预致敏淋巴细胞来诱导。CTL及其前体细胞全身分布于外周淋巴结和脾脏，尽管它们有归巢至同源淋巴组织的倾向。从这些淋巴组织获得的淋巴细胞可产生直接细胞毒性，并且从这些淋巴组织获得的细胞在过继转移后40 - 60天可通过混合淋巴细胞肿瘤细胞培养反应产生继发性细胞毒性反应。此外，淋巴结和脾细胞对细胞毒性的诱导具有协同作用。这些发现表明肿瘤免疫广泛分布，并且各种淋巴细胞群体参与了高效细胞介导的细胞毒性反应的产生。
