Pediatría, Centro Salud amante Laffón, ESPAÑA.
PEDIATRIA, Clínica Santa Isabel. Sevilla, España.
Rev Esp Enferm Dig. 2019 Feb;111(2):134-139. doi: 10.17235/reed.2018.5559/2018.
the secretion of antigens from the diet into breast milk has been extensively documented. The transfer of gliadin could be critical for the development of an immune response.
to investigate the presence of immunogenic gluten peptides in the feces of infants fed with different diets.
a blind, prospective, controlled, collaborative study was performed in three hospitals, between September 2016 and January 2017. The study protocol was approved by the Ethics Committee of the hospitals in Seville prior to starting the study.
the cohort was divided into three groups of 30 infants: an experimental group (average age 9.2 ± 2.8 weeks) with exclusive breastfeeding, a control group 1 (average age 10.3 ± 3.3 weeks) exclusively fed with onset formula and a control group 2 (average age 56 ± 3.7 weeks) with infants that consumed gluten on a regular basis. The peptide 33-mer of gliadin was negative in all feces samples from both the experimental and control group 1. With regard to control group 2, the peptide 33-mer of gliadin was negative in 23% of cases (seven children). There was no difference in the amount of gluten ingested by these children compared to those who excreted the 33-mer peptide.
the failure to detect gluten in the feces of infants that were exclusively breastfed indicates that it is probably below the limits of detection. Healthy children who consume gluten may not excrete it in feces.
饮食中的抗原分泌到母乳中已被广泛证实。麦胶蛋白的转移可能对免疫反应的发展至关重要。
研究不同饮食喂养的婴儿粪便中是否存在免疫原性谷蛋白肽。
本研究于 2016 年 9 月至 2017 年 1 月在三家医院进行了一项盲法、前瞻性、对照、协作研究。该研究方案在开始研究前已获得塞维利亚医院伦理委员会的批准。
该队列分为三组，每组 30 名婴儿：实验组（平均年龄 9.2 ± 2.8 周）进行纯母乳喂养，对照组 1（平均年龄 10.3 ± 3.3 周）进行配方奶喂养，对照组 2（平均年龄 56 ± 3.7 周）为常规摄入谷蛋白的婴儿。实验组和对照组 1 的所有粪便样本中均未检测到麦胶蛋白 33 肽。至于对照组 2，23%（7 名儿童）的粪便中麦胶蛋白 33 肽为阴性。与排泄 33 肽的儿童相比，这些儿童摄入的谷蛋白量没有差异。
纯母乳喂养的婴儿粪便中未检测到谷蛋白，这表明其含量可能低于检测限。健康食用谷蛋白的儿童粪便中可能不排泄它。
