a The Engineering Technology Research Center for Functional Textiles in Higher Education of Guangdong Province, School of Textile Materials and Engineering , Wuyi University , Jiangmen , Guangdong , China.
b State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine , Shanghai Jiao Tong University , Shanghai , China.
J Biomater Sci Polym Ed. 2019 Jan;30(1):64-76. doi: 10.1080/09205063.2018.1549771. Epub 2019 Jan 11.
Long-term antibacterial medical dressings can prevent infection as skin wounds heal. In this study, we used the hydrophobic antibacterial drug amoxicillin as a model to prepare drug-loaded nanomicelles using a film dispersion-hydration method, and drug-loaded nanomicelles were coaxially electrospun into nanofiber to create a novel nanomicelle-in-nanofiber (NM-in-NF) drug delivery system. Scanning electron microscopy and transmission electron microscopy were used to characterize the morphology of nanomicelles and nanofibers. Thermal property of as-prepared samples was tested using differential scanning calorimetry. The drug release behavior, cytotoxicity, and antibacterial properties of NM-in-NFs were examined in vitro to evaluate the system's potential to be used in the treatment of skin wounds. Experimental results indicated that the novel NM-in-NF system had dual controlled release effect, which greatly reduced burst release and prolonged effective drug duration. Moreover, NM-in-NFs was also found to be safe and non-toxic, with a broad-spectrum antibacterial activity. It thus could potentially be used in long-term antibacterial medical dressings to treat skin wounds.
长效抗菌医用敷料可在皮肤伤口愈合过程中预防感染。在本研究中，我们以疏水性抗菌药物阿莫西林为模型，采用薄膜分散-水化法制备载药纳米胶束，然后将载药纳米胶束同轴电纺成纳米纤维，构建了一种新颖的纳米胶束-纳米纤维（NM-in-NF）给药系统。扫描电子显微镜和透射电子显微镜用于表征纳米胶束和纳米纤维的形态。采用差示扫描量热法测试了所制备样品的热性能。通过体外实验考察了 NM-in-NFs 的药物释放行为、细胞毒性和抗菌性能，以评估该系统用于治疗皮肤创伤的潜力。实验结果表明，新型 NM-in-NF 系统具有双重控制释放效果，大大降低了药物的突释效应，延长了有效药物作用时间。此外，NM-in-NFs 还表现出安全无毒、广谱抗菌的特性。因此，它有可能被用于长效抗菌医用敷料以治疗皮肤创伤。
