Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Via Celoria 10, 20133, Milan, Italy.
GenPhySE, INRA, Université de Toulouse, INPT, ENVT, 31326, Castanet Tolosan, France.
Genet Sel Evol. 2018 Nov 19;50(1):55. doi: 10.1186/s12711-018-0423-9.
International standard panels of single nucleotide polymorphisms (SNPs) have replaced microsatellites in several species for parentage assessment and assignment (PA) purposes. However, such a resource is still lacking in goats. The application of a cheap tool for PA would help the management of goat populations by improving the reliability of pedigree registration and, consequently, allow a better implementation of breeding schemes or conservation programs.
Using data from the current GoatSNP50 chip, starting from a worldwide dataset of more than 4000 animals belonging to more than 140 breeds and populations from the AdaptMap initiative, we selected a panel of 195 SNPs. The assignment rate of this panel was up to 100% on an additional dataset that included 2000 Alpine and Saanen animals and highly related candidate sires.
In this study, we defined a highly informative SNP panel, which will be publicly available to worldwide breeders and laboratories. Its development on such a large number of breeds and populations, together with validation on a second set of cosmopolitan breeds, makes it a promising and important genomic tool for the goat species.
在一些物种中，国际标准的单核苷酸多态性 (SNP) 面板已经取代了微卫星，用于亲子关系评估和分配 (PA)。然而，在山羊中，这种资源仍然缺乏。廉价的 PA 工具的应用将有助于管理山羊种群，提高系谱登记的可靠性，从而更好地实施育种计划或保护计划。
利用当前 GoatSNP50 芯片的数据，从 AdaptMap 计划中属于 140 多个品种和种群的 4000 多只动物的全球数据集出发，我们选择了 195 个 SNP 组成的面板。该面板在包括 2000 只阿尔卑斯山羊和萨能山羊以及高度相关的候选父本的额外数据集上的分配率达到了 100%。
在这项研究中，我们定义了一个信息量很大的 SNP 面板，它将向全球的饲养者和实验室公开。它在如此多的品种和种群上的发展，以及在第二个全球化品种集上的验证，使其成为山羊物种的一个有前途和重要的基因组工具。
