Department of Medicine, Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, 622 West 168th Street PH1273, New York, NY 10032, USA.
Department of Medicine, Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, 622 West 168th Street PH1273, New York, NY 10032, USA.
Heart Fail Clin. 2019 Jan;15(1):97-107. doi: 10.1016/j.hfc.2018.08.010. Epub 2018 Oct 24.
Women with advanced heart failure (HF) are underrepresented in trials of short-term and durable mechanical circulatory support although they derive similar benefit. In acute HF, intensive medical and interventional therapies are effective but underutilized. The smaller, newer generation, left ventricular assist devices (LVADs) have increased the feasibility of durable support in women. Women frequently present late, with more comorbidities, emphasizing the need for timely referral. Compared with men, the stroke risk is higher in women with an LVAD. Increased representation in clinical trials and a better understanding of the psychosocial issues affecting women is essential.
患有晚期心力衰竭（HF）的女性在短期和持久机械循环支持的试验中代表性不足，尽管她们从中受益相似。在急性 HF 中，强化的医疗和介入治疗是有效的，但未得到充分利用。较小、更新一代的左心室辅助装置（LVAD）增加了女性持久支持的可行性。女性常常出现较晚，合并症更多，这强调了及时转诊的必要性。与男性相比，LVAD 女性的中风风险更高。在临床试验中增加代表性以及更好地了解影响女性的社会心理问题至关重要。
