Tan Hong Pin, Conroy Tiffany
J Perianesth Nurs. 2018 Dec;33(6):865-879. doi: 10.1016/j.jopan.2017.05.010. Epub 2017 Oct 9.
Intravenous (IV) opioids are administered for management of acute postoperative pain in the postanesthesia care unit. The benefits of parenteral oxycodone for acute pain management are understudied. The purpose of this review was to evaluate the effectiveness of IV oxycodone for acute postoperative pain.
A systematic review of quantitative studies using the Joanna Briggs Institute approach.
A search for randomized controlled trials was conducted, revealing 314 potentially relevant studies. These were compared with the inclusion criteria. Those that met these criteria were critically appraised.
Participants (N = 506) in eight trials were included in this review. Four studies supported the use of IV oxycodone as patient-controlled analgesia and IV bolus. The remaining studies showed equipotent effects between oxycodone and control. Higher incidences of adverse effects were associated with IV oxycodone.
IV oxycodone can be considered as effective analgesia for acute postoperative pain with careful regards to its adverse effects.
静脉注射阿片类药物用于麻醉后护理单元中急性术后疼痛的管理。胃肠外使用羟考酮治疗急性疼痛的益处尚未得到充分研究。本综述的目的是评估静脉注射羟考酮治疗急性术后疼痛的有效性。
采用乔安娜·布里格斯研究所方法对定量研究进行系统综述。
检索随机对照试验，共找到314项可能相关的研究。将这些研究与纳入标准进行比较。符合标准的研究进行严格评价。
本综述纳入了八项试验中的506名参与者。四项研究支持将静脉注射羟考酮用于患者自控镇痛和静脉推注。其余研究表明羟考酮与对照药物效果相当。静脉注射羟考酮会导致更高的不良反应发生率。
考虑到静脉注射羟考酮的不良反应，可将其视为治疗急性术后疼痛的有效镇痛方法。
