Euskirchen Philipp, Peyre Matthieu
Department of Neurology, Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany; Berlin Institute of Health (BIH), 10178 Berlin, Germany; German Cancer Consortium (DKTK), partner site Berlin, Germany; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Hôpital Pitié-Salpêtrière, service de Neurochirurgie, 75013 Paris, France; CRICM INSERM U1127 CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Unité de Neuro-oncologie expérimentale, 75013 Paris, France; Sorbonne Universités, Paris, France.
Presse Med. 2018 Nov-Dec;47(11-12 Pt 2):e245-e252. doi: 10.1016/j.lpm.2018.05.016. Epub 2018 Nov 16.
Meningiomas are the most frequent primary brain tumors, accounting for ∼37% of central nervous systems tumors. Despite being largely benign, clinicians frequently face difficult treatment decisions in cases with complex morphology or localisation, near vital brain structures such as the optic nerve or in the case of incidental tumors. Here, we review current concepts of diagnosis, treatment and follow-up with clinical decision-making informed by multimodal imaging, histology, and molecular biology.
脑膜瘤是最常见的原发性脑肿瘤，约占中枢神经系统肿瘤的37%。尽管大多为良性，但在形态复杂或位置特殊的病例中，如靠近视神经等重要脑结构处或偶然发现的肿瘤，临床医生常常面临艰难的治疗决策。在此，我们结合多模态影像学、组织学和分子生物学知识，对当前脑膜瘤的诊断、治疗及随访的概念以及临床决策进行综述。
