Cheung M Y, Ho A Wh, Wong S H
Department of Orthopaedics and Traumatology, Caritas Medical Centre, Sham Shui Po, Hong Kong.
Hong Kong Med J. 2018 Dec;24(6):579-583. doi: 10.12809/hkmj187227. Epub 2018 Nov 19.
Patients who sustain an osteoporotic fracture are at increased risk of sustaining further osteoporotic fracture. The risk can be reduced by prescription of anti-osteoporosis medication. The aim of the present study was to determine the current practice in Hong Kong regarding secondary drug prevention of fragility fractures after osteoporotic hip fracture.
Dispensation of anti-osteoporosis medication records from patients with new fragility hip fractures aged ≥65 years were retrieved using the Hospital Authority Clinical Data Analysis and Reporting System from 2009 to 2012. The intervention rate each year was determined from the percentage of patients receiving anti-osteoporosis medication within 1 year after hip fracture.
A total of 15 866 patients with osteoporotic hip fracture who met the criteria were included. The intervention rate differed each year from 2009 to 2012, ranging between 9% and 15%. Orthopaedic surgeons initiated 63% of anti-osteoporosis medication, whereas physicians initiated 37%. The anti-osteoporosis drugs being prescribed included alendronic acid (76%), ibandronic acid (12%), strontium ranelate (5%), and zoledronic acid (4%).
Most patients with hip fracture remained untreated for 1 year after the osteoporotic hip fracture. The Hospital Authority should allocate more resources to implement a best practice framework for treatment of patients with hip fracture at high risk of secondary fracture.
发生骨质疏松性骨折的患者再次发生骨质疏松性骨折的风险增加。通过开具抗骨质疏松药物可降低该风险。本研究的目的是确定香港目前在骨质疏松性髋部骨折后脆性骨折二级药物预防方面的做法。
利用医院管理局临床数据分析及报告系统检索2009年至2012年年龄≥65岁的新发脆性髋部骨折患者的抗骨质疏松药物配药记录。每年的干预率由髋部骨折后1年内接受抗骨质疏松药物治疗的患者百分比确定。
共纳入15866例符合标准的骨质疏松性髋部骨折患者。2009年至2012年每年的干预率不同,在9%至15%之间。骨科医生启动了63%的抗骨质疏松药物治疗,而内科医生启动了37%。所开具的抗骨质疏松药物包括阿仑膦酸(76%)、伊班膦酸(12%)、雷奈酸锶(5%)和唑来膦酸(4%)。
大多数髋部骨折患者在骨质疏松性髋部骨折后1年内仍未接受治疗。医院管理局应分配更多资源,以实施针对继发性骨折高危髋部骨折患者的最佳治疗实践框架。