Jafarirad Sima, Ayoobi Nina, Karandish Majid, Jalali Mohammad-Taha, Haghighizadeh Mohammad Hossein, Jahanshahi Alireza
Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Int J Prev Med. 2018 Oct 12;9:86. doi: 10.4103/ijpvm.IJPVM_339_17. eCollection 2018.
An appropriate snack for patients with diabetes mellitus should be considered to help them in their treatment due to their hard administrative diet. This study was conducted to evaluate the effect of dark chocolate on inflammatory markers, serum adiponectin, and certain biochemical factors in patients with type 2 diabetes (T2D).
This study was a randomized parallel clinical trial. Thirty grams of 84% dark chocolate, along with therapeutic lifestyle changes (TLCs) guidelines, were administrated to patients with T2D. Control group received only TLC guidelines. The intervention period was 8 weeks. Twenty-one subjects in dark chocolate and 23 subjects in control group completed the study. Fasting blood samples were collected before and after the intervention period and inflammatory markers, biochemical factors, and adiponectin levels were assessed.
Fasting blood sugar, hemoglobin A1C, low-density lipoprotein and triglyceride levels declined significantly in the dark chocolate group and this decrease was significant between the intervention and control groups. Tumor necrosis factor-alpha, interleukin-6, and high sensitive C-reactive protein were significantly decreased in the dark chocolate group. Adiponectin levels were not significantly different between the two groups.
In this study subjects who received dark chocolate along with TLC guidelines had lower levels of inflammatory markers such as hs-CRP, TNF-α, and IL-6, compared with the subjects who were devoid of dark chocolate and followed only the TLC guidelines. Other studies should be conducted to evaluate the most effective and administrative dosage of dark chocolate as a snack along with the common treatment of diabetes.
由于糖尿病患者饮食管理严格，应考虑为他们提供合适的零食以辅助治疗。本研究旨在评估黑巧克力对2型糖尿病（T2D）患者炎症标志物、血清脂联素及某些生化因子的影响。
本研究为随机平行临床试验。将30克84%的黑巧克力与治疗性生活方式改变（TLC）指南一起应用于T2D患者。对照组仅接受TLC指南。干预期为8周。黑巧克力组的21名受试者和对照组的23名受试者完成了研究。在干预期前后采集空腹血样，评估炎症标志物、生化因子和脂联素水平。
黑巧克力组的空腹血糖、糖化血红蛋白、低密度脂蛋白和甘油三酯水平显著下降，且干预组与对照组之间的这种下降具有显著性。黑巧克力组的肿瘤坏死因子-α、白细胞介素-6和高敏C反应蛋白显著降低。两组之间的脂联素水平无显著差异。
在本研究中，与仅遵循TLC指南而未食用黑巧克力的受试者相比，同时接受黑巧克力和TLC指南的受试者的炎症标志物如hs-CRP、TNF-α和IL-6水平较低。应开展其他研究以评估作为零食的黑巧克力与糖尿病常规治疗联合使用时的最有效及可行剂量。
