Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Nutrition and Health Sciences, College of Education and Human Sciences, University of Nebraska-Lincoln, Nebraska, USA.
Phytother Res. 2021 Oct;35(10):5487-5501. doi: 10.1002/ptr.7183. Epub 2021 Jun 5.
Due to the increasing rate of cardiovascular disease and related risk factors in the worldin recent decades, the present meta-analysis was performed to investigate the effects ofcocoa/chocolate consumption on lipid profile, glycemia, and blood pressure control in diabetic patients. A systematic search of the databases PubMed, Scopus, Web of Science, and Cochran Library was performed up to July 2020. All randomized controlled trials (RCTs) using cocoa/dark chocolate in diabetic patients were included in the study. The search results were limited to English-language publications. Eight RCTs, including 433 participants, were selected for this meta-analysis. Pooled analysis indicated a significant reduction in low-density lipoprotein cholesterol LDL-c levels (WMD: -15.49 mg/dl; 95% CI: -24.56, -6.42, p = .001) and fasting blood sugar (FBS) concentrations (WMD: -6.88 mg/dl; 95% CI: -13.28, -0.48, p = .03) following cocoa/dark chocolate consumption. The analysis of papers included in current study indicates that the consumption of cocoa/dark chocolate reduced the serum fasting blood glucose (FBS) and LDL cholesterol concentrations. However, further high quality trials are essential for confirming the clinical efficacy of cocoa/dark chocolate consumption on complete metabolic profile.
由于近几十年来全球心血管疾病及其相关危险因素的发病率不断上升，本荟萃分析旨在探讨可可/巧克力的摄入对糖尿病患者血脂谱、血糖和血压控制的影响。截至 2020 年 7 月，对 PubMed、Scopus、Web of Science 和 Cochrane Library 数据库进行了系统检索。研究纳入了所有使用可可/黑巧克力治疗糖尿病患者的随机对照试验（RCT）。检索结果仅限于英文出版物。本荟萃分析纳入了 8 项 RCT，共 433 名参与者。汇总分析表明，可可/黑巧克力摄入可显著降低低密度脂蛋白胆固醇（LDL-c）水平（WMD：-15.49mg/dl；95%CI：-24.56，-6.42，p=0.001）和空腹血糖（FBS）浓度（WMD：-6.88mg/dl；95%CI：-13.28，-0.48，p=0.03）。纳入研究的文献分析表明，可可/黑巧克力的摄入可降低血清空腹血糖（FBS）和 LDL 胆固醇浓度。然而，还需要进行高质量的试验来证实可可/黑巧克力摄入对完整代谢谱的临床疗效。
