Sayed Angeliqua, Valente Mariana, Sassoon David
Cellular, Molecular, and Physiological Mechanisms of Heart Failure, Paris-Cardiovascular Research Center (PARCC), European Georges Pompidou Hospital (HEGP), INSERM U970, F-75737 Paris Cedex 15, Paris, France.
F1000Res. 2018 Nov 6;7. doi: 10.12688/f1000research.15609.1. eCollection 2018.
Embryonic heart progenitors arise at specific spatiotemporal periods that contribute to the formation of distinct cardiac structures. In mammals, the embryonic and fetal heart is hypoxic by comparison to the adult heart. In parallel, the cellular metabolism of the cardiac tissue, including progenitors, undergoes a glycolytic to oxidative switch that contributes to cardiac maturation. While oxidative metabolism is energy efficient, the glycolytic-hypoxic state may serve to maintain cardiac progenitor potential. Consistent with this proposal, the adult epicardium has been shown to contain a reservoir of quiescent cardiac progenitors that are activated in response to heart injury and are hypoxic by comparison to adjacent cardiac tissues. In this review, we discuss the development and potential of the adult epicardium and how this knowledge may provide future therapeutic approaches for cardiac repair.
胚胎心脏祖细胞在特定的时空阶段出现，这些阶段有助于形成不同的心脏结构。与成年心脏相比，哺乳动物的胚胎和胎儿心脏处于缺氧状态。与此同时，包括祖细胞在内的心脏组织的细胞代谢经历了从糖酵解到氧化的转变，这有助于心脏成熟。虽然氧化代谢能量效率高，但糖酵解-缺氧状态可能有助于维持心脏祖细胞的潜能。与这一观点一致的是，已证明成年心外膜含有静止心脏祖细胞库，这些祖细胞在心脏损伤时被激活，与相邻心脏组织相比处于缺氧状态。在这篇综述中，我们讨论了成年心外膜的发育和潜能，以及这些知识如何为心脏修复提供未来的治疗方法。
