基因多态性与根尖外吸收之间的关联：一项系统评价和荟萃分析。
Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis.
作者信息
Nowrin Shifat A, Jaafar Saidi, Ab Rahman Norma, Basri Rehana, Alam Mohammad Khursheed, Shahid Fazal
机构信息
Orthodontic Unit, School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Craniofacial Biology Research Group, School of Dental Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
出版信息
Korean J Orthod. 2018 Nov;48(6):395-404. doi: 10.4041/kjod.2018.48.6.395. Epub 2018 Sep 14.
OBJECTIVE
To date, only a few studies have investigated the relationships between genetic polymorphisms and external apical root resorption (EARR). Hence, the aim of this systematic review was to explore the relationship between different gene polymorphisms and their association with EARR.
METHODS
A complete literature search was conducted by two independent reviewers. The PubMed, Science Direct, and Scopus databases were searched. In addition, the bibliographies of all textbooks and relevant articles were searched manually. A meta-analysis was performed using data entered into the electronic databases until February 28, 2017.
RESULTS
On the basis of the search, we identified 17 and 7 publications for the systematic review and meta-analysis, respectively. Odds ratio (OR) was used to evaluate the association of the interleukin 1B (+3954) polymorphism and the risk of EARR. The overall OR from the studies was used to estimate the risk of EARR. However, no association was found and no publication bias was apparent for the risk of EARR in patients receiving orthodontic treatment.
CONCLUSIONS
More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions.
目的
迄今为止，仅有少数研究探讨了基因多态性与根尖外吸收（EARR）之间的关系。因此，本系统评价的目的是探究不同基因多态性与EARR之间的关系及其关联性。
方法
由两名独立的审阅者进行全面的文献检索。检索了PubMed、Science Direct和Scopus数据库。此外，还手动检索了所有教科书和相关文章的参考文献。使用录入电子数据库的数据进行荟萃分析，截至2017年2月28日。
结果
基于检索，我们分别确定了17篇和7篇用于系统评价和荟萃分析的出版物。采用比值比（OR）评估白细胞介素1B（+3954）多态性与EARR风险的关联性。研究的总体OR用于估计EARR的风险。然而，未发现接受正畸治疗患者的EARR风险存在关联，也未发现明显的发表偏倚。
结论
需要对基因多态性与EARR之间的关系进行更多研究，以确定可能相互作用的更好特异性。
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