Adigun Nurudeen S, Oladiji A Temidayo, Ajiboye Taofeek O
Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
Antioxidants Redox Biology and Toxicology Research Group, Department of Medical Biochemistry College of Health Sciences, Nile University of Nigeria, FCT-Abuja, Nigeria.
J Diet Suppl. 2020;17(1):53-66. doi: 10.1080/19390211.2018.1482982. Epub 2018 Nov 17.
This study evaluates the anti-hyperlipidaemic and antioxidant activities of hydro-ethanolic fruits extract of in hyperlipidemia rats. The secondary volatile metabolite constituents of the extract were identified using Gas chromatography. antioxidant activity of the extract (0.2-1.0 mg/mL) was investigated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydrogen peroxide (HO) and hydroxyl radical (OH). antioxidant and anti-hyperlipidaemic properties of the extract were evaluated in triton X-100-induced hyperlipidaemic rats. Gas chromatogram indicates the presence of 13 compounds with tans β-ocimene being the major constituent. The extract scavenged DPPH, HO and OH radicals in concentrations dependent manner. reversed triton X-100-mediated increase in serum total cholesterol, triglycerides and low-density lipoprotein, and reduction in high-density lipoprotein. Triton X-100-mediated decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phospahte dehydrogenase were significantly reversed by the extract. The results indicate that has antioxidant and anti-hyperlipidaemic properties.
本研究评估了[植物名称]水乙醇果实提取物对高脂血症大鼠的降血脂和抗氧化活性。采用气相色谱法鉴定提取物中的次生挥发性代谢物成分。使用2,2-二苯基-1-苦基肼（DPPH）自由基、过氧化氢（HO）和羟基自由基（OH）研究提取物（0.2 - 1.0 mg/mL）的抗氧化活性。在 Triton X - 100诱导的高脂血症大鼠中评估提取物的抗氧化和降血脂特性。气相色谱图表明存在13种化合物，其中反式β-罗勒烯为主要成分。提取物以浓度依赖的方式清除DPPH、HO和OH自由基。它逆转了Triton X - 100介导的血清总胆固醇、甘油三酯和低密度脂蛋白的升高以及高密度脂蛋白的降低。提取物显著逆转了Triton X - 100介导的超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶和葡萄糖6 - 磷酸脱氢酶的降低。结果表明[植物名称]具有抗氧化和降血脂特性。
