一项全国性医疗保健人群队列研究中的性别差异、紫外线暴露与恶性雀斑样痣风险。
Gender differences, UV exposure and risk of lentigo maligna in a nationwide healthcare population cohort study.
机构信息
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
出版信息
J Eur Acad Dermatol Venereol. 2019 Jul;33(7):1268-1271. doi: 10.1111/jdv.15348. Epub 2018 Dec 5.
BACKGROUND
Our understanding of the relationship between ultraviolet (UV) radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumours incidence.
OBJECTIVE
To examine the association of UV light with LM by gender remains unclear.
METHODS
Two prospective cohort study [Nurses' Health Study (1980-2012)] and [Health Professionals Follow-up Study (1986-2010)] were analysed. All participants with LM or MIS, non-LM type were included in analysis. UV index at birth, age 15, and age 30 were calculated by gender. Lifetime UV flux was calculated. Hazard ratios (HRs) were calculated.
RESULTS
A total of 110 485 women from NHS and 41 015 men from HPFS were examined. A total of 281 LM and 776 melanoma in situ (MIS), non-LM cases were reported. Risk of LM increased with increasing UV flux exposure in multivariate-adjusted models for men (P for trend = 0.04), but not for women (P for trend = 0.91).
CONCLUSIONS
UV flux may be associated with LM in men but not in women.
背景
我们对紫外线 (UV) 辐射暴露与恶性雀斑样痣 (LM) 之间关系的了解主要来自基于侵袭性黑色素瘤的流行病学/临床研究。最近的研究表明，黑素细胞肿瘤的发病率存在性别差异。
目的
通过性别来检查紫外线与 LM 之间的关联尚不清楚。
方法
分析了两项前瞻性队列研究[护士健康研究（1980-2012 年）]和[卫生专业人员随访研究（1986-2010 年）]。所有患有 LM 或 MIS、非 LM 型的患者均纳入分析。按性别计算出生时、15 岁和 30 岁的 UV 指数。计算终生紫外线通量。计算风险比 (HR)。
结果
共检查了 NHS 的 110485 名女性和 HPFS 的 41015 名男性。共报告了 281 例 LM 和 776 例非 LM 黑色素瘤原位 (MIS) 病例。在男性多变量调整模型中，随着 UV 通量暴露的增加，LM 的风险增加（趋势 P = 0.04），但在女性中则没有（趋势 P = 0.91）。
结论
紫外线通量可能与男性的 LM 有关，但与女性无关。
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