Cohen L M
Pathology Services, Inc., Cambridge, MA 02139, USA.
J Am Acad Dermatol. 1995 Dec;33(6):923-36; quiz 937-40. doi: 10.1016/0190-9622(95)90282-1.
Lentigo maligna (LM) is a pigmented lesion that occurs on the sun-exposed skin, particularly the head and neck areas, of an older patient. The lesion increases in size and at some point, often many years after its onset, may become lentigo maligna melanoma (LMM). For this reason, most authors consider LM a form of melanoma in situ. Treatment includes surgical or destructive modalities; the preferred form of therapy is surgical removal. Histopathologic features include a proliferation of atypical melanocytes along the basal layer of the epidermis and adnexal structures. This article discusses the clinical, histopathologic, and epidemiologic features of LM. The prognosis and treatment of LM are reviewed. Although the lifetime risk of the development of LMM is unclear, LMM is discussed briefly.
恶性雀斑（LM）是一种色素沉着性病变，发生于老年患者暴露于阳光下的皮肤，尤其是头颈部区域。该病变会增大，并且在发病后的某个时间点，通常是发病多年后，可能会发展为恶性雀斑样黑色素瘤（LMM）。因此，大多数作者认为LM是原位黑色素瘤的一种形式。治疗方法包括手术或破坏性手段；首选的治疗方式是手术切除。组织病理学特征包括非典型黑素细胞沿表皮基底层和附属器结构增生。本文讨论了LM的临床、组织病理学和流行病学特征。对LM的预后和治疗进行了综述。尽管LMM发生的终生风险尚不清楚，但也对LMM进行了简要讨论。
