Côté Nathalie, Pasquier Jean-Charles
Département d'obstétrique-gynécologie et département de microbiologie et infectiologie, université de Sherbrooke, 3001 12e avenue Nord, Sherbrooke, Québec (J1H 5H3), Canada - Département d'obstétrique-gynécologie, université de Sherbrooke, 3001 12e avenue Nord, Sherbrooke, Québec (J1H 5H3), Canada.
Med Sci (Paris). 2018 Oct;34(10):799-805. doi: 10.1051/medsci/2018205. Epub 2018 Nov 19.
Preterm birth is the leading cause of perinatal mortality and morbidity. Despite the efforts spent over the past 40 years to solve the physiopathological processes involved in the triggering of prematurity, efficient therapeutics are still lacking. Recently, growing body of evidence suggests that the maternal microbiome is a major player for a normal pregnancy and that dysbiosis is associated with preterm birth. The vaginal microbiome and its commensal Lactobacillus species may protect the uterus of ascending dissemination of pathogens. The uterus can also be contaminated with oral bacteria by the blood stream. Thus, the maternal microbiome can play both a protective role or a causal role in the triggering of preterm birth.
早产是围产期死亡率和发病率的主要原因。尽管在过去40年里人们致力于解决引发早产的生理病理过程，但仍缺乏有效的治疗方法。最近，越来越多的证据表明，母体微生物群是正常妊娠的主要参与者，而生态失调与早产有关。阴道微生物群及其共生的乳酸杆菌属物种可能保护子宫免受病原体上行传播的影响。子宫也可能通过血流被口腔细菌污染。因此，母体微生物群在早产的触发过程中既可以起到保护作用，也可以起到因果作用。
