肠道菌群失调与早产：益生菌是否发挥作用？
Dysbiosis and Prematurity: Is There a Role for Probiotics?
机构信息
Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy.
出版信息
Nutrients. 2019 Jun 5;11(6):1273. doi: 10.3390/nu11061273.
Abstract
Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.
摘要
健康的微生物群是维持健康的关键介质，人们认为菌群失调可能在多种疾病的发病机制中起作用。有证据支持这样一种假说，即母体菌群失调可能是早产的触发因素；早产儿肠道的异常定植可能在喂养不耐受和坏死性小肠结肠炎的发病机制中起作用。尽管进行了多项临床试验和荟萃分析，但仍不清楚用益生菌补充剂来调节产妇和新生儿的微生物群是否能降低早产及其并发症的风险。
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