Lazon de la Jara Percy, Diec Jennie, Naduvilath Thomas, Papas Eric B
Brien Holden Vision Institute, Sydney, New South Wales, Australia.
Vision Cooperative Research Centre, Sydney, New South Wales, Australia.
Optom Vis Sci. 2018 Dec;95(12):1088-1095. doi: 10.1097/OPX.0000000000001304.
Since becoming a popular form of refractive error correction, contact lenses have aspired to replicate the nonwearer experience. This study assessed how well currently available daily disposable soft lenses have achieved that goal, using a graphical representation to show individual lens behavior relative to benchmarks.
The purpose of this study was to assess comfort, vision, and adverse events during daily disposable contact lens wear, relative to emmetropes and spectacle wearers.
Three-month clinical studies, where participants either wore one of five daily disposable contact lenses (n = 201), were full-time spectacle wearers with no history of contact lens wear (n = 34), or emmetropic non-contact lens wearers (n = 40). Vision quality and comfort were assessed at the beginning and end of the day (1 to 10). Corneal infiltrative events were recorded. Between-group comparisons were made using a linear mixed model and literature estimates of clinical significance.
Initial comfort among emmetropes (mean ± 95% confidence interval, 8.0 ± 0.5) was not significantly different from any of the lens types (range, 7.2 ± 0.4 to 8.0 ± 0.4, all P > .06) or spectacle wearers (7.3 ± 0.5, P = .45). Comfort deteriorated during the day in all groups (P < .05). End-of-day comfort for emmetropes (7.3 ± 0.6) was significantly better, only than lenses B (5.7 ± 0.6, P < .001) and D (6.2 ± 0.5, P = .01). Vision quality for emmetropes (8.6 ± 0.5) was better than spectacle wearers (7.8 ± 0.5, P = .04) and lenses A (7.6 ± 0.4, P = .003) and B (7.5 ± 0.4, P < .001). Corneal infiltrative events occurred in 0% of emmetropes and 2.9% of spectacle wearers and ranged from 2.4 to 7.5% in lens wearers.
Under the conditions of this study, comfort and vision with some contemporary daily disposable contact lenses were indistinguishable from nonwearing emmetropes. Although the contact lens-wearing groups had rates of corneal infiltrative events that were not statistically different from the nonwearers, the study had insufficient power to permit robust conclusions in this respect.
自从成为一种流行的屈光不正矫正方式以来，隐形眼镜一直致力于重现不佩戴者的体验。本研究评估了目前市面上的日抛型软性隐形眼镜在实现这一目标方面的表现，采用图形表示法展示了各款镜片相对于基准的个体行为。
本研究的目的是评估日抛型隐形眼镜佩戴期间的舒适度、视力和不良事件，并与正视者和佩戴框架眼镜者进行比较。
为期三个月的临床研究，参与者分别佩戴五款日抛型隐形眼镜中的一款（n = 201）、从未佩戴过隐形眼镜的长期框架眼镜佩戴者（n = 34）或正视且不佩戴隐形眼镜者（n = 40）。在一天开始和结束时评估视力质量和舒适度（1至10分）。记录角膜浸润事件。采用线性混合模型和临床意义的文献估计进行组间比较。
正视者的初始舒适度（均值±95%置信区间，8.0±0.5）与任何一款隐形眼镜类型（范围为7.2±0.4至8.0±0.4，所有P>.06）或框架眼镜佩戴者（7.3±0.5，P =.45）相比均无显著差异。所有组的舒适度在一天中均有所下降（P<.05）。正视者的日间结束时舒适度（7.3±0.6）仅显著优于镜片B（5.7±0.6，P<.001）和镜片D（6.2±0.5，P =.01）。正视者的视力质量（8.6±0.5）优于框架眼镜佩戴者（7.8±0.5，P =.04）以及镜片A（7.6±0.4，P =.003）和镜片B（7.5±,0.4，P<.001）。角膜浸润事件在0%的正视者和2.9%的框架眼镜佩戴者中发生，在隐形眼镜佩戴者中的发生率为2.4%至7.5%。
在本研究条件下，一些当代日抛型隐形眼镜的舒适度和视力与未佩戴隐形眼镜的正视者无差异。尽管隐形眼镜佩戴组的角膜浸润事件发生率与未佩戴者相比无统计学差异，但该研究在这方面的检验效能不足以得出有力结论。
