The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
College of Nursing, University of Utah, Salt Lake City, Utah, USA.
J Pain Symptom Manage. 2019 Feb;57(2):183-189. doi: 10.1016/j.jpainsymman.2018.11.010. Epub 2018 Nov 17.
Symptoms are reported to co-occur during treatment for breast cancer. We previously identified three patterns of fatigue and two patterns of disturbed sleep, depressed mood, and anxiety in women undergoing chemotherapy for breast cancer using a Latent Growth Mixture Model.
The purpose of this study was to explore whether membership in symptom classes of fatigue, disturbed sleep, depressed mood, and anxiety is associated with other symptoms at moderate-to-severe levels.
Using data from three longitudinal studies, Wilcoxon rank-sum tests and Jonckheere-Terpstra tests for trend were used to distinguish between classes of women on co-occurring symptoms. Summative scores were calculated, including the number of days subjects reported moderate-to-severe levels (4 or higher on a 0-10 scale) of seven symptoms during two cycles of chemotherapy and compared to class membership.
Participants (n = 166) in the higher fatigue severity class reported more days with moderate-to-severe disturbed sleep, depressed mood, anxiety, nausea, and trouble thinking. Women in the higher severity disturbed sleep class reported more days with moderate-to-severe fatigue, depressed mood, anxiety, and trouble thinking. Women in the higher depressed mood severity class reported more days with moderate-to-severe fatigue, disturbed sleep, anxiety, and nausea. Women in the higher anxiety severity class reported more days with moderate-to-severe fatigue, disturbed sleep, and depressed mood.
Moderate-to-severe symptoms co-occur during cancer treatment for breast cancer. The dynamic process of multiple symptoms may be altered by future identification of a shared etiology.
在乳腺癌治疗过程中，会出现各种症状。我们之前使用潜在增长混合模型在接受乳腺癌化疗的女性中确定了三种疲劳模式和两种睡眠障碍、抑郁情绪和焦虑模式。
本研究旨在探讨疲劳、睡眠障碍、抑郁情绪和焦虑症状类别的成员是否与其他中度至重度水平的症状相关。
使用来自三项纵向研究的数据，Wilcoxon 秩和检验和 Jonckheere-Terpstra 检验趋势用于区分不同的女性共病症状类别的女性。计算综合评分，包括两个化疗周期中报告中度至重度水平（0-10 量表上的 4 或更高）的七种症状的天数，并与类别成员进行比较。
（n=166）高疲劳严重程度类别的参与者报告了更多天的中度至重度睡眠障碍、抑郁情绪、焦虑、恶心和思维困难。高睡眠障碍严重程度类别的女性报告了更多天的中度至重度疲劳、抑郁情绪、焦虑和思维困难。高抑郁情绪严重程度类别的女性报告了更多天的中度至重度疲劳、睡眠障碍、焦虑和恶心。高焦虑严重程度类别的女性报告了更多天的中度至重度疲劳、睡眠障碍和抑郁情绪。
乳腺癌治疗过程中会出现中度至重度症状。多种症状的动态过程可能会因未来确定共同病因而改变。
