Waldhauser M, Schramek P
Department of Urology, University of Vienna, Austria.
J Urol. 1988 Sep;140(3):525-7. doi: 10.1016/s0022-5347(17)41709-5.
The efficiency and side effects of a single dose of intracorporeally applied prostaglandin E1 (20 mcg.) in inducing penile erection were examined. In addition, the effect of this dose of prostaglandin E1 was compared to the effect of 7.5 mg. papaverine plus 0.25 mg. phentolamine in a double-blind, crossover designed study. We tested twice 12 men 52.9 +/- 7.6 years old (mean +/- standard deviation) with erectile dysfunction. On 1 occasion the subjects received 20 mcg. prostaglandin E1 and on the other they received 7.5 mg. papaverine and 0.25 mg. phentolamine. At this dosage prostaglandin E1 was most effective in inducing artificial penile erection (11 of 12 patients). However, 75 per cent of the subjects reported burning sensations during the entire period of erection and in 1 prostaglandin E1 treatment resulted in a sustained erection. At the doses used, prostaglandin E1 was more effective in inducing penile erection than papaverine plus phentolamine (11 versus 6 patients). Intracavernous injection of prostaglandin E1 is a potent tool for artificial penile erection and warrants precise examination for its potential clinical use.
研究了单剂量经体内应用前列腺素E1（20微克）诱导阴茎勃起的有效性和副作用。此外，在一项双盲、交叉设计的研究中，将该剂量前列腺素E1的效果与7.5毫克罂粟碱加0.25毫克酚妥拉明的效果进行了比较。我们对12名年龄为52.9±7.6岁（平均值±标准差）的勃起功能障碍男性进行了两次测试。受试者一次接受20微克前列腺素E1，另一次接受7.5毫克罂粟碱和0.25毫克酚妥拉明。在此剂量下，前列腺素E1在诱导人工阴茎勃起方面最有效（12名患者中有11名）。然而，75%的受试者在整个勃起期间报告有烧灼感，在1例中，前列腺素E1治疗导致了持续性勃起。在所使用的剂量下，前列腺素E1在诱导阴茎勃起方面比罂粟碱加酚妥拉明更有效（分别为11例和6例患者）。海绵体内注射前列腺素E1是诱导人工阴茎勃起的有效手段，值得对其潜在临床应用进行精确研究。
