Abdallah H M
Department of Urology, Ain Shams University, Cairo, Egypt.
Int Urol Nephrol. 1998;30(5):617-20. doi: 10.1007/BF02550556.
The efficiency and side effects of a single dose of 20 mcg of intracorporeally applied Alprostadil (Caverject, Upjohn), a prostaglandin E1, in inducing penile erection were examined in 30 patients. In addition, the effect of this dose of prostaglandin E1 was compared to that of 30 mg of papaverine plus 0.5 mg of regitine (phentolamine). All patients received a first injection of the combination of the vasoactive drugs and a second injection of the prescribed dose of Caverject. The degree of erection, time interval between injections and achievement of full erection as well as side effects during and after injection were compared. All patients had a burning sensation during the injection of Caverject. Two patients given the vasoactive combination got priapism and were evacuated; this complication was not reported for Caverject. In the doses used Caverject was superior to papaverine plus phentolamine in inducing penile erection and in achieving a higher grade of erection.
对30例患者进行了研究，观察单次体内注射20微克前列腺素E1（凯威捷，优普强公司生产）诱导阴茎勃起的疗效及副作用。此外，还将该剂量前列腺素E1的效果与30毫克罂粟碱加0.5毫克立其丁（酚妥拉明）的效果进行了比较。所有患者均先注射一次血管活性药物组合，然后再注射规定剂量的凯威捷。比较了勃起程度、两次注射的时间间隔、完全勃起的达成情况以及注射期间和之后的副作用。所有患者在注射凯威捷时均有烧灼感。两名接受血管活性药物组合治疗的患者发生阴茎异常勃起并进行了处理；凯威捷未报告出现该并发症。在所使用的剂量下，凯威捷在诱导阴茎勃起及达到更高勃起程度方面优于罂粟碱加酚妥拉明。
