Curcumin loading potentiates the neuroprotective efficacy of FeO magnetic nanoparticles in cerebellum cells of schizophrenic rats.

BACKGROUND

The aim of this study was to investigate the neurotoxic effects of FeO magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model.

METHODS

We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (FeO magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of FeO magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove FeO magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membrane potential collapse, mitochondrial complex II activity, reactive oxygen species generation, ATP level, cytochrome c release and histopathology of cerebellums were determined in brains of schizophrenic rats.

RESULTS

We showed that effective treatment with CMN reduced or prevented FeO magnetic-induced oxidative stress and mitochondrial dysfunction in the rat brain probably, as well as mitochondrial complex II activity, MMP, and ATP level were remarkably reduced in the cerebellum mitochondria of treated group toward control (p < 0.05). Therewith, ROS generation, and cytochrome c release were notably (p < 0.05) increased in the cerebellum mitochondria of treated group compared with control group.

CONCLUSION

Taken together, FeO magnetic- CurNPs exhibits potent antineurotoxicity activity in cerebellums of schizophrenic rats. This approach can be extended to preclinical and clinical use and may have importance in schizophernia treatment in the future. To our knowledge this is the first report that provides the FeO magnetic- CurNPs could enhance the neuroprotective effects of CMN in the Schizophrenia.