单侧肾血管性高血压患者的肾静脉血浆肾素活性

Renal vein plasma renin activity in patients with unilateral renovascular hypertension.

作者信息

Sato K, Abe K, Seino M, Yasujima M, Imai Y, Sato M, Hiwatari M, Omata K, Tanno M, Kohzuki M

机构信息

Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Jpn Circ J. 1988 May;52(5):431-6. doi: 10.1253/jcj.52.431.

DOI:10.1253/jcj.52.431

PMID:3045359

Abstract

Plasma renin activity in the renal veins (V) or infrarenal inferior vena cavae (IVC) of 20 patients with unilateral renovascular hypertension (RVH) was measured to determine how renal vein renin ratio (RVRR) compares with renin index (V-IVC/IVC) as a predictor of curability of RVH. Although there was no significant difference between them in predicting curability, 3 out of 4 patients with hypersecretion of renin (V-IVC/IVC greater than or equal to 0.48) in the stenosed side with contralateral suppression (V-IVC/IVC less than or equal to 0) on the normal side were cured. In addition, 7 out of 11 patients with contralateral suppression irrespective of values of renin index in the stenosed side were also cured. On the other hand, only one out of 6 patients who had neither hypersecretion nor contralateral suppression was cured. These results reconfirm that significant renin secretion with or without contralateral suppression, or only contralateral suppression of renin is highly suggestive of curable RVH.

摘要

测量了20例单侧肾血管性高血压（RVH）患者肾静脉（V）或肾下下腔静脉（IVC）中的血浆肾素活性，以确定肾静脉肾素比值（RVRR）与肾素指数（V-IVC/IVC）作为RVH可治愈性预测指标的比较情况。尽管它们在预测可治愈性方面没有显著差异，但在狭窄侧肾素分泌过多（V-IVC/IVC大于或等于0.48）且正常侧对侧抑制（V-IVC/IVC小于或等于0）的4例患者中，有3例治愈。此外，在狭窄侧不论肾素指数值如何而出现对侧抑制的11例患者中，有7例也治愈。另一方面，在既无分泌过多也无对侧抑制的6例患者中，只有1例治愈。这些结果再次证实，有或无对侧抑制的显著肾素分泌，或仅肾素的对侧抑制，高度提示RVH可治愈。