一种来自肺草的新型萘甲醛衍生物及其抗烟草花叶病毒（抗TMV）活性
[A new naphthaldehyde derivative from Comastoma pulmonarium and its anti-tobacco mosaic virus (anti-TMV) activity].
作者信息
Wang Xiao-Long, Li Ping, Li Jing, Chen Jian-Hua, Yang Guang-Yu, Hu Qiu-Fen, Zhang Cheng-Ming, Li Gan-Peng
机构信息
Key Laboratory of Chemistry in Ethnic Medicinal Resource, State Ethnic Affairs Commission and Ministry of Education, Yunnan Minzu University, Kunming 650500, China.
Technology Center, China Tobacco Yunnan industrial Co., Ltd., Kunming 650106, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2018 Oct;43(19):3884-3886. doi: 10.19540/j.cnki.cjcmm.20180807.009.
A new naphthaldehyde derivative has been isolated from Comastoma pulmonarium by using various chromatographic techniques, including silica gel, Sephadex LH-20, MCI-gel resin and RP-HPLC. This compounds was determined as 5-methoxy-2-methyl-7-(2-oxopropyl)naphthalene-1-carbaldehyde(1) by NMR, MS, IR and UV spectra. This compound was also evaluated for its anti-tobacco mosaic virus (anti-TMV) activity. The result showed that it showed high anti-TMV activity with inhibition rate of 32.8%. The inhibition rate is close to that of positive control (ningnanmycin).
通过使用各种色谱技术，包括硅胶、葡聚糖凝胶LH-20、MCI凝胶树脂和反相高效液相色谱，从肺草夹竹桃中分离出一种新的萘甲醛衍生物。通过核磁共振、质谱、红外光谱和紫外光谱将该化合物确定为5-甲氧基-2-甲基-7-(2-氧代丙基)萘-1-甲醛(1)。还对该化合物的抗烟草花叶病毒(抗TMV)活性进行了评估。结果表明，它表现出高抗TMV活性，抑制率为32.8%。该抑制率与阳性对照(宁南霉素)相近。
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