[从腺毛唐松草中分离得到的一种新型抗病毒异喹啉生物碱]
[A new antiviral isoquinoline alkaloid from Thalictrum glandulosissimum].
作者信息
Luo Dian, Lyu Na, Liao Ling-Min, Gao Qian, Li Yin-Ke, Li Jing, Liu Xin, Li Xue-Mei, Yang Guang-Yu, Ye Yan-Qing, Hu Qiu-Fen, Dong Miao
机构信息
College of Chinese National Medicine, Yunnan Minzu University Kunming 650500, China Technology Center, China Tobacco Yunnan Industrial Co., Ltd. Kunming 650106, China.
Technology Center, China Tobacco Yunnan Industrial Co., Ltd. Kunming 650106, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(11):2568-2570. doi: 10.19540/j.cnki.cjcmm.20200229.203.
A new isoquinoline alkaloid(1) has been isolated from the whole plant of Thalictrum glandulosissimum by using various chromatographic techniques, including silica gel, sephadex, MCI-gel resin, and RP-HPLC, and its structure was determined as 1-(6-hydroxy-7-methylisoquinolin-1-yl) ethantone by physicochemical properties and spectroscopic data. This compound was evaluated for anti-tobacco mosaic virus(TMV) activity. The results showed that it had prominent anti-TMV activity with inhibition rates of 28.4%. This rate was closed to that of positive control.
通过使用各种色谱技术，包括硅胶、葡聚糖凝胶、MCI-凝胶树脂和反相高效液相色谱，从腺毛唐松草全株中分离出一种新的异喹啉生物碱（1），并通过物理化学性质和光谱数据确定其结构为1-（6-羟基-7-甲基异喹啉-1-基）乙酮。对该化合物进行了抗烟草花叶病毒（TMV）活性评估。结果表明，它具有显著的抗TMV活性，抑制率为28.4%。该抑制率与阳性对照接近。
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