幽门螺杆菌感染与胃食管反流病的关联
Association of Helicobacter pylori infection with gastroesophageal reflux disease.
作者信息
Jie Wu, Qinghong Xu, Zhitao Chen
机构信息
1 Department of Gastroenterology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology; Wuhan, Hubei Province, China.
2 Medical College of Jianghan University, Wuhan, Hubei Province, China.
出版信息
J Int Med Res. 2019 Feb;47(2):748-753. doi: 10.1177/0300060518809871. Epub 2018 Nov 19.
OBJECTIVE
Many studies have shown that Helicobacter pylori ( Hp) is negatively correlated with gastroesophageal reflux disease (GERD). Moreover, some studies deny that eradication of Hp increases the incidence of GERD. Therefore, we investigated the association of Hp infection with GERD.
METHODS
In this retrospective analysis, patients with peptic ulcers were used as a blank control group. We used logistic regression to analyze the relationship between Hp infection and GERD. We analyzed 953 patients with peptic ulcers, 180 patients with both peptic ulcers and GERD, and 298 patients with GERD.
RESULTS
Among the patients with GERD, 75.6% (136/180) and 36.2% (108/298) of those with and without peptic ulcers, respectively, had Hp infection, and the difference was statistically significant. Among patients with peptic ulcers, 75.6% (136/180) and 67.4% (642/953) of those with and without GERD, respectively, had Hp infection. The incidence of GERD in patients with Hp-positive and -negative peptic ulcers was 17.5% (136/778) and 12.4% (44/355), respectively. These differences were also statistically significant.
CONCLUSION
In the analysis of patients with GERD, the prevalence of Hp infection was higher among patients with than without peptic ulcers.
目的
许多研究表明，幽门螺杆菌（Hp）与胃食管反流病（GERD）呈负相关。此外，一些研究否认根除Hp会增加GERD的发病率。因此，我们研究了Hp感染与GERD之间的关联。
方法
在这项回顾性分析中，将消化性溃疡患者作为空白对照组。我们使用逻辑回归分析Hp感染与GERD之间的关系。我们分析了953例消化性溃疡患者、180例同时患有消化性溃疡和GERD的患者以及298例GERD患者。
结果
在GERD患者中，患有和未患有消化性溃疡的患者中分别有75.6%（136/180）和36.2%（108/298）感染了Hp，差异具有统计学意义。在消化性溃疡患者中，患有和未患有GERD的患者中分别有75.6%（136/180）和67.4%（642/953）感染了Hp。Hp阳性和阴性的消化性溃疡患者中GERD的发病率分别为17.5%（136/778）和12.4%（4,4/355）。这些差异也具有统计学意义。
结论
在对GERD患者的分析中，患有消化性溃疡的患者中Hp感染的患病率高于未患有消化性溃疡的患者。
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