Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Infect Dis. 2022 Mar 19;22(1):267. doi: 10.1186/s12879-022-07278-6.
The association between H. pylori (Helicobacter pylori) infection and gastroesophageal reflux disease (GERD) is a complex and confusing subject. The aim of this study was to evaluate the association between helicobacter pylori infection and erosive gastroesophageal reflux disease.
In a cross-sectional study, all patients referred for endoscopy due to dyspepsia were enrolled. The diagnosis of erosive GERD was made by endoscopy. Patients with normal esophagus were selected as comparison group. Random gastric biopsies were taken from all participants to diagnose H. pylori infection.
In total, 1916 patients were included in this study, of whom 45.6% had GERD. The mean age (SD) was 42.95 (16.32). Overall, 1442 (75.3%) patients were positive for H. pylori infection. The frequency of H. pylori infection in mild GERD patients was higher than the severe GERD, but this difference was not significant (P = 0.214). Except for sociodemographic status (P < 0.001), other variables including gender, age, ethnicity, body mass index (BMI), smoking, and presence of hiatus hernia in patients had no significant association with the frequency of H. pylori infection. According to Robust Poisson regression models analysis, the association of H. pylori (PR 1.026; 95% CI 0.990-1.064; P = 0.158) and sociodemographic status were not significantly different between the two groups. But smoking, increased BMI, older age, presence of hiatus hernia, and peptic ulcer diseases were significantly associated with GERD compared with the non-GERD group.
In our results, there was no association between H. pylori infection and erosive GERD. Further studies are recommended.
幽门螺杆菌（Helicobacter pylori）感染与胃食管反流病（GERD）之间的关联是一个复杂而令人困惑的问题。本研究旨在评估幽门螺杆菌感染与糜烂性胃食管反流病之间的关联。
在一项横断面研究中，所有因消化不良而接受内镜检查的患者均被纳入研究。通过内镜诊断糜烂性 GERD。选择食管正常的患者作为对照组。所有参与者均随机取胃活检以诊断幽门螺杆菌感染。
本研究共纳入 1916 例患者，其中 45.6%患有 GERD。平均年龄（标准差）为 42.95（16.32）岁。总体而言，1442 例（75.3%）患者幽门螺杆菌感染阳性。轻度 GERD 患者的幽门螺杆菌感染频率高于重度 GERD，但差异无统计学意义（P=0.214）。除社会人口统计学特征（P<0.001）外，其他变量（包括性别、年龄、种族、体重指数、吸烟和食管裂孔疝的存在）与幽门螺杆菌感染频率之间无显著相关性。根据稳健泊松回归模型分析，幽门螺杆菌（PR 1.026；95%CI 0.990-1.064；P=0.158）与社会人口统计学状况在两组间无显著差异。但与非 GERD 组相比，吸烟、BMI 增加、年龄较大、存在食管裂孔疝和消化性溃疡病与 GERD 显著相关。
在我们的研究结果中，幽门螺杆菌感染与糜烂性 GERD 之间无关联。建议进一步开展研究。
