Miyake Yoshihiro, Tanaka Keiko, Okubo Hitomi, Sasaki Satoshi, Arakawa Masashi
Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan.
Research Promotion Unit, Translational Research Center, Ehime University Hospital, Ehime, Japan.
Nutr Neurosci. 2020 Sep;23(9):706-713. doi: 10.1080/1028415X.2018.1548139. Epub 2018 Nov 19.
The current prebirth cohort study investigated the relationship between maternal B vitamin intake during pregnancy and behavioral problems in Japanese children aged 5 years. Subjects were 1199 mother-child pairs. Dietary intake was assessed using a diet history questionnaire. Emotional problems, conduct problems, hyperactivity problems, peer problems, and low prosocial behavior were examined using the Japanese parent-report version of the Strengths and Difficulties Questionnaire. Adjustment was made for maternal age, gestation at baseline, region of residence, number of children, maternal and paternal education, household income, maternal depressive symptoms, alcohol intake, vitamin B complex supplement use, smoking during pregnancy, child's birth weight, child's sex, breastfeeding duration, and smoking in the household during the first year of life. Maternal folate intake during pregnancy was independently inversely associated with childhood low prosocial behavior: the adjusted odds ratio (OR) (95% confidence interval [CI], for trend) between extreme quartiles was 0.55 (0.37-0.80, 0.0002). Maternal vitamin B intake during pregnancy was independently inversely related to childhood hyperactivity problems and low prosocial behavior: the adjusted ORs (95% CIs, for trend) between extreme quartiles were 0.57 (0.34-0.94, 0.01) and 0.58 (0.40-0.85, 0.0009), respectively. Maternal vitamin B intake during pregnancy was independently inversely associated with childhood emotional problems: the adjusted OR (95% CI, for trend) between extreme quartiles was 0.58 (0.33-0.99, 0.11). Maternal intake of folate, vitamin B, and vitamin B during pregnancy may be protective against childhood low prosocial behavior, hyperactivity problems and low prosocial behavior, and emotional problems, respectively.
当前的出生队列研究调查了孕期母亲维生素B摄入量与5岁日本儿童行为问题之间的关系。研究对象为1199对母婴。通过饮食史问卷评估饮食摄入量。使用日本家长报告版的长处与困难问卷对情绪问题、品行问题、多动问题、同伴问题和低亲社会行为进行了检查。对母亲年龄、基线孕周、居住地区、子女数量、父母教育程度、家庭收入、母亲抑郁症状、酒精摄入量、复合维生素B补充剂使用情况、孕期吸烟、孩子出生体重、孩子性别、母乳喂养持续时间以及孩子出生后第一年家庭吸烟情况进行了校正。孕期母亲叶酸摄入量与儿童低亲社会行为独立呈负相关：极端四分位数之间的校正比值比（OR）（95%置信区间[CI]，趋势）为0.55（0.37 - 0.80，P = 0.0002）。孕期母亲维生素B摄入量与儿童多动问题和低亲社会行为独立呈负相关：极端四分位数之间的校正OR（95% CI，趋势）分别为0.57（0.34 - 0.94，P = 0.01）和0.58（0.40 - 0.85，P = 0.0009）。孕期母亲维生素B摄入量与儿童情绪问题独立呈负相关：极端四分位数之间的校正OR（95% CI，趋势）为0.58（0.33 - 0.99，P = 0.11）。孕期母亲叶酸、维生素B和维生素B的摄入可能分别对儿童低亲社会行为、多动问题和低亲社会行为以及情绪问题具有保护作用。
