Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):510-513. doi: 10.1016/j.bbrc.2018.11.078. Epub 2018 Nov 16.
Peroxidase activity of cytochrome c stimulated by interaction of the protein with cardiolipin is considered to be involved in the induction of mitochondrial apoptosis associated with cytochrome c release from mitochondria. In model systems, this activity has been previously shown to cause permeabilization of cardiolipin-containing membranes. Here, we found that the antibiotic minocycline, known to have neuroprotective properties, inhibited both the binding of cyt c to cardiolipin-containing membranes and the cyt c/HO-induced liposome permeabilization. The results could be relevant to inhibition of cyt c release from mitochondria exerted by minocycline.
细胞色素 c 与心磷脂相互作用所刺激的过氧化物酶活性被认为与细胞色素 c 从线粒体释放相关的线粒体凋亡的诱导有关。在模型系统中，先前已经表明这种活性会导致含有心磷脂的膜的通透性增加。在这里，我们发现，已知具有神经保护特性的抗生素米诺环素抑制细胞色素 c 与含有心磷脂的膜的结合以及细胞色素 c/HO 诱导的脂质体通透性。这些结果可能与米诺环素抑制细胞色素 c 从线粒体中的释放有关。
