胎儿膜结构、妊娠和分娩中的衰老和炎症。
Fetal membrane architecture, aging and inflammation in pregnancy and parturition.
机构信息
Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
Division of Maternal-Fetal Medicine & Perinatal Research, Department of Obstetrics & Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA.
出版信息
Placenta. 2019 Apr;79:40-45. doi: 10.1016/j.placenta.2018.11.003. Epub 2018 Nov 10.
Abstract
Preterm birth is the single major cause of infant mortality. Short and long term outcomes for infants are often worse in cases of preterm premature rupture of the fetal membranes (pPROM). Thus, increased knowledge of the structure characteristics of fetal membranes as well as the mechanisms of membrane rupture are essential if we are to develop effective treatment strategies to prevent pPROM. In this review, we focus on the role of inflammation and senescence in fetal membrane biology.
摘要
早产是婴儿死亡的主要原因。在胎膜早破（pPROM）的情况下，婴儿的短期和长期预后往往更差。因此，如果我们要开发有效的治疗策略来预防 pPROM，就必须增加对胎膜结构特征和破裂机制的了解。在这篇综述中，我们重点讨论了炎症和衰老在胎膜生物学中的作用。
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