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市售啤酒的遗传毒理学评价。II. 市售啤酒产品在鼠伤寒沙门氏菌TA98、TA100和TA102菌株中的致突变活性。

Genetic toxicology evaluation of commercial beers. II. Mutagenic activity of commercial beer products in Salmonella typhimurium strains TA98, TA100 and TA102.

作者信息

Brusick D J, Jagannath D R, Myhr B, Sernau R, Chappel C I

机构信息

Hazleton Laboratories America Inc., Kensington, MD 20895.

出版信息

Mutat Res. 1988 Sep;206(1):41-6. doi: 10.1016/0165-1218(88)90139-5.

DOI:10.1016/0165-1218(88)90139-5
PMID:3045536
Abstract

5 concentrated extracts of commercial beers were prepared using XAD-2 resin. The residues were subjected to evaluation for mutagenic activity in Salmonella typhimurium strains TA98, TA100 and TA102. The tests were conducted using preincubation protocols including provisions for S9 metabolic activation. Although the extracts did produce moderate toxicity to the Salmonella organisms used in the assays, none of the residues were found to induce mutation up to their maximum testable concentrations.

摘要

使用XAD - 2树脂制备了5种市售啤酒的浓缩提取物。对残留物进行了鼠伤寒沙门氏菌TA98、TA100和TA102菌株的致突变活性评估。测试采用预孵育方案，包括S9代谢活化。虽然提取物对测定中使用的沙门氏菌确实产生了中度毒性，但在其最高可测试浓度下，未发现任何残留物能诱导突变。

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