Yvert Thomas P, Zempo Hirofumi, Gabdrakhmanova Leysan J, Kikuchi Naoki, Miyamoto-Mikami Eri, Murakami Haruka, Naito Hisashi, Cieszczyk Pawel, Leznicka Katarzyna, Kostryukova Elena S, Alexeev Dmitry G, Egorova Emiliya S, Maciejewska-Skrendo Agnieszka, Larin Andrey K, Generozov Edward V, Kulemin Nickolay A, Ospanova Elena A, Pavlenko Alexander V, Sawczuk Marek, Zmijewski Piotr, Lulinska-Kuklik Ewelina, Govorun Vadim M, Miyachi Motohiko, Ahmetov Ildus I, Fuku Noriyuki
Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan.
Department of Basic Biomedical Sciences, Universidad Europea de Madrid, Madrid, Spain.
Biol Sport. 2018 Jun;35(2):105-109. doi: 10.5114/biolsport.2018.71599. Epub 2017 Nov 23.
We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene () rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of the rs11091046 polymorphism among 282 track and field sprint/power athletes (200 men and 82 women), including several national record holders and Olympic medallists (214 Japanese, 68 Russian and Polish), and 2024 control subjects (842 men and 1182 women) (804 Japanese, 1220 Russian and Polish). In men, a meta-analysis from the two combined cohorts showed a significantly higher frequency of the C allele in athletes than in controls (odds ratio: 1.62, =0.008, heterogeneity index =0%). With regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls (67.7% vs. 55.9%, =0.022), but not in Russian/Polish male athletes (61.9% vs. 51.0%, =0.172). In women, no significant results were obtained by meta-analysis for the two cohorts combination (=0.850). The AC genotype frequency was significantly higher in Russian/Polish women athletes than in controls (69.2% vs. 42.1%, =0.022), but not in Japanese women athletes (=0.226). Our results, in contrast to previous findings, suggested by meta-analysis that the C allele of the rs11091046 polymorphism is associated with sprint/power track and field athlete status in men, but not in women.
我们旨在针对特定的体育赛事群体（仅田径项目）以及两个不同种族（日本人以及东欧人，即俄罗斯人和波兰人），复制最初的研究结果，该结果显示血管紧张素 II 2 型受体基因（）rs11091046 A>C 多态性与运动员身份之间存在关联。我们比较了 282 名田径短跑/力量型运动员（200 名男性和 82 名女性）中 rs11091046 多态性的基因型频率，这些运动员包括几位全国纪录保持者和奥运奖牌获得者（214 名日本人、68 名俄罗斯人和波兰人），以及 2024 名对照受试者（842 名男性和 1182 名女性）（804 名日本人、1220 名俄罗斯人和波兰人）。在男性中，对两个合并队列进行的荟萃分析显示，运动员中 C 等位基因的频率显著高于对照组（优势比：1.62，=0.008，异质性指数 =0%）。就各个队列而言，日本男性运动员中 C 等位基因频率高于对照组（67.7% 对 55.9%，=0.022），但俄罗斯/波兰男性运动员中并非如此（61.9% 对 51.0%，=0.172）。在女性中，对两个队列组合进行的荟萃分析未获得显著结果（=0.850）。俄罗斯/波兰女性运动员中 AC 基因型频率显著高于对照组（69.2% 对 42.1%，=0.022），但日本女性运动员中并非如此（=0.226）。与之前的研究结果相反，我们的结果通过荟萃分析表明，rs11091046 多态性的 C 等位基因与男性田径短跑/力量型运动员身份相关，但与女性无关。
