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放射肿瘤学为何要开展转化研究?[已修正]

Why should radiation oncology do translational research? [corrected].

作者信息

Cañas Rut, Linares Isabel, Guedea Ferran, Berenguer Miguel Ángel

机构信息

Department of Radiobiology and Cancer, ONCOBELL - IDIBELL, Barcelona, Spain.

Radiation Oncology Department. Institut Català d'Oncologia, L'Hospitalet de Llobregat, Avinguda Granvia, 199-203, 08908, Barcelona, Spain.

出版信息

Rep Pract Oncol Radiother. 2019 Jan-Feb;24(1):60-64. doi: 10.1016/j.rpor.2018.10.008. Epub 2018 Nov 12.

DOI:10.1016/j.rpor.2018.10.008
PMID:30455615
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6234255/
Abstract

Radiological Oncology, like the rest of medical specialties, is beginning to provide can personalized therapies. The ongoing scientific advances enable a great degree of precision in diagnoses and therapies. To fight cancer, from a radiotherapy unit, requires up-to-date equipment, professionals with different specialties working in synchrony (doctors, physicists, biologists, etc.) and a lot of research. Some of the new therapeutic tendencies are immunotherapy, nanoparticles, gene therapy, biomarkers, artificial intelligence, etc. A new clinical paradigm in which new professional networks are inevitable is arising. The mission of translational research is to become a scientific engine in the clinical space.

摘要

放射肿瘤学与其他医学专科一样,正开始提供个性化治疗。不断取得的科学进展使诊断和治疗能够达到很高的精准度。要在放疗科对抗癌症,需要有最新的设备、不同专业的人员协同工作(医生、物理学家、生物学家等)以及大量研究。一些新的治疗趋势包括免疫疗法、纳米颗粒、基因疗法、生物标志物、人工智能等。一种新的临床范式正在出现,在这种范式中,新的专业网络是不可避免的。转化研究的使命是成为临床领域的科学引擎。

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本文引用的文献

1
Overview of ongoing clinical trials investigating combined radiotherapy and immunotherapy.正在进行的联合放疗与免疫疗法临床试验概述。
Immunotherapy. 2018 Aug;10(10):851-0. doi: 10.2217/imt-2018-0019.
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Radiotherapy-Controllable Chemotherapy from Reactive Oxygen Species-Responsive Polymeric Nanoparticles for Effective Local Dual Modality Treatment of Malignant Tumors.基于活性氧响应性聚合物纳米粒子的放疗可控化疗用于恶性肿瘤的有效局部双重模式治疗
Biomacromolecules. 2018 Sep 10;19(9):3825-3839. doi: 10.1021/acs.biomac.8b00942. Epub 2018 Aug 9.
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Application of Multifunctional Nanomaterials in Radioprotection of Healthy Tissues.多功能纳米材料在健康组织辐射防护中的应用。
Adv Healthc Mater. 2018 Oct;7(20):e1800421. doi: 10.1002/adhm.201800421. Epub 2018 Jul 17.
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Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors.单样本乳腺癌放射敏感性基因表达预测因子的鉴定和验证。
Breast Cancer Res. 2018 Jul 4;20(1):64. doi: 10.1186/s13058-018-0978-y.
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Intraoperative Radiation Therapy (IORT): A Series of 1000 Tumors.术中放射治疗(IORT):1000 例肿瘤系列。
Ann Surg Oncol. 2018 Oct;25(10):2987-2993. doi: 10.1245/s10434-018-6614-3. Epub 2018 Jul 2.
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Complete Local and Abscopal Responses from a Combination of Radiation and Nivolumab in Refractory Hodgkin's Lymphoma.在难治性霍奇金淋巴瘤中,联合使用放疗和纳武利尤单抗可产生完全的局部和远隔效应。
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Nanotechnology Approaches to Improving Cancer Immunotherapy.纳米技术在改善癌症免疫疗法中的应用
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Intraoperative radiation therapy as part of planned monotherapy for early-stage breast cancer.术中放射治疗作为早期乳腺癌计划性单一疗法的一部分。
J Radiat Oncol. 2018;7(2):167-173. doi: 10.1007/s13566-017-0338-z. Epub 2017 Dec 19.
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Comparison of Local Recurrence Among Early Breast Cancer Patients Treated With Electron Intraoperative Radiotherapy vs Hypofractionated Photon Radiotherapy an Observational Study.早期乳腺癌患者术中电子放疗与大分割光子放疗局部复发情况的比较:一项观察性研究
Front Oncol. 2018 Jun 5;8:207. doi: 10.3389/fonc.2018.00207. eCollection 2018.
10
Artificial intelligence in radiation oncology: A specialty-wide disruptive transformation?人工智能在放射肿瘤学中的应用:是否会引发全专业范围的颠覆性变革?
Radiother Oncol. 2018 Dec;129(3):421-426. doi: 10.1016/j.radonc.2018.05.030. Epub 2018 Jun 12.