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[结直肠癌的流行病学和病理学特征:约36例报告]

[Epidemiological and pathological profile of colorectal cancer: about 36 cases].

作者信息

Belhamidi Mohamed Said, Sinaa Mohamed, Kaoukabi Abdessamad, Krimou Hicham, Menfaa Mohamed, Sakit Farid, Choho Abdelkrim

机构信息

Service de Chirurgie Viscérale, Hôpital Militaire Moulay Ismail, Meknès, Maroc.

Laboratoire d'Anatomopathologie, Hôpital Militaire Moulay Ismail, Meknès, Maroc.

出版信息

Pan Afr Med J. 2018 Jun 22;30:159. doi: 10.11604/pamj.2018.30.159.15061. eCollection 2018.

DOI:10.11604/pamj.2018.30.159.15061
PMID:30455788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6235491/
Abstract

Colorectal cancer is classified among the most common cancers in the world (after breast cancer and prostate cancer) and it is the second digestive tract cancer in Morocco after stomach cancer. However, its incidence in our country is lower than that of western countries (2.5 to 3.3 / 100 000 ha) but it coincides with that of Maghreb countries where this cancer affects young subjects in 27% of cases. Colorectal cancer (CRC) is one of the best examples of multistep carcinogenesis. Knowing the anatomopathological characteristics of CRC will certainly affect our therapeutic approaches. We conducted a retrospective epidemiological and anatomopathological study in the Department of Visceral Surgery at the Military Hospital Moulay Ismail, Meknes over a period of 5 years from January 2012 to December 2016. The study involved 36 patients: 14 women and 22 men. The aim of this study was to analyze the epidemiological profile and the anatomopathological features of colorectal cancers. The analysis of our results shows a specific epidemiological profile which is characteristic of a type of colorectal cancer affecting younger subjects, mainly male patients. Sporadic carcers are largely predominant, occurring mainly in the rectosigmoid region. A low degree of differentiation of adenocarcinomas with mucinous features is correlated with advanced TNM and Aster Coller staging and with lymph node status with poor prognosis. This multidisciplinary approach will be a novelty at national level, thus making our structure of clinical practice and research one of the centres for multidisciplinary management of colorectal cancer in Morocco.

摘要

结直肠癌是世界上最常见的癌症之一(仅次于乳腺癌和前列腺癌),在摩洛哥是继胃癌之后的第二大消化道癌症。然而,我国结直肠癌的发病率低于西方国家(2.5至3.3/10万人口),但与马格里布国家的发病率一致,在这些国家,27%的病例中该癌症影响年轻患者。结直肠癌(CRC)是多步骤致癌过程的最佳例子之一。了解结直肠癌的解剖病理学特征肯定会影响我们的治疗方法。我们于2012年1月至2016年12月在梅克内斯穆莱·伊斯梅尔军事医院内脏外科进行了一项为期5年的回顾性流行病学和解剖病理学研究。该研究涉及36名患者:14名女性和22名男性。本研究的目的是分析结直肠癌的流行病学特征和解剖病理学特征。对我们结果的分析显示出一种特定的流行病学特征,这是一种影响年轻患者(主要是男性患者)的结直肠癌类型所特有的。散发性癌症占主导地位,主要发生在直肠乙状结肠区域。具有黏液特征的腺癌低分化程度与晚期TNM和阿斯特·科勒分期以及预后不良的淋巴结状态相关。这种多学科方法在国家层面将是一种创新,从而使我们的临床实践和研究机构成为摩洛哥结直肠癌多学科管理的中心之一。

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本文引用的文献

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Gastroenterol Clin Biol. 2006 Apr;30(4):598-603. doi: 10.1016/s0399-8320(06)73234-1.
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Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition.肉类、鱼类与结直肠癌风险:欧洲癌症与营养前瞻性调查
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Colorectal cancer in the young: a 12-year review of patients 30 years or less.青年结直肠癌:对30岁及以下患者的12年回顾
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6
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BMJ. 2000 Sep 30;321(7264):805-8. doi: 10.1136/bmj.321.7264.805.
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[Adenomas and other dysplastic flat polyps of the colon].[结肠腺瘤及其他发育异常的扁平息肉]
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