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粪便微生物群移植对一名慢性顽固性便秘患者的疗效。

Efficacy of fecal microbiota transplantation in a patient with chronic intractable constipation.

作者信息

Ohara Tadashi, Suzutani Tatsuo

机构信息

Department of Intestinal Bioscience and Medicine School of Medicine Fukushima Medical University Fukushima City Japan.

Department of Microbiology School of Medicine Fukushima Medical University Fukushima City Japan.

出版信息

Clin Case Rep. 2018 Sep 9;6(11):2029-2032. doi: 10.1002/ccr3.1798. eCollection 2018 Nov.

DOI:10.1002/ccr3.1798
PMID:30455884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6230666/
Abstract

We have presented the first case report of FMT therapy for a patient with chronic intractable constipation. This therapy resulted in good, medium-term outcomes. Follow-up analysis of the intestinal flora suggested that transplanted microbes from the donor, particularly and cluster IX, may have been incorporated into the recipient.

摘要

我们报告了首例针对慢性顽固性便秘患者的粪菌移植（FMT）治疗病例。该治疗产生了良好的中期效果。对肠道菌群的后续分析表明，来自供体的移植微生物，特别是IX簇，可能已整合到受体中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8056/6230666/bdcbb182d022/CCR3-6-2029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8056/6230666/bdcbb182d022/CCR3-6-2029-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8056/6230666/bdcbb182d022/CCR3-6-2029-g001.jpg

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本文引用的文献

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Dysbiosis Signatures of Gut Microbiota Along the Sequence from Healthy, Young Patients to Those with Overweight and Obesity.肠道微生物群沿着从健康年轻患者到超重和肥胖患者的序列的失调特征。
Obesity (Silver Spring). 2018 Feb;26(2):351-361. doi: 10.1002/oby.22088. Epub 2017 Dec 27.
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The gut microbiome and liver cancer: mechanisms and clinical translation.肠道微生物群与肝癌：机制及临床转化
Nat Rev Gastroenterol Hepatol. 2017 Sep;14(9):527-539. doi: 10.1038/nrgastro.2017.72. Epub 2017 Jul 5.
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Microbial Interactions and Interventions in Colorectal Cancer.
使用 16s rRNA 扩增子测序鉴定粪菌移植治疗慢性难治性便秘后的微生物多样性。
PLoS One. 2019 Mar 19;14(3):e0214085. doi: 10.1371/journal.pone.0214085. eCollection 2019.
肠道微生物相互作用及其在结直肠癌防治中的干预
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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites.从膳食纤维到宿主生理：短链脂肪酸作为关键的细菌代谢产物
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Duodenal infusion of donor feces for recurrent Clostridium difficile.经十二指肠输注供体粪便治疗复发性艰难梭菌感染。
N Engl J Med. 2013 Jan 31;368(5):407-15. doi: 10.1056/NEJMoa1205037. Epub 2013 Jan 16.
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Alternative method for gas chromatography-mass spectrometry analysis of short-chain fatty acids in faecal samples.粪便样本中短链脂肪酸的气相色谱-质谱分析的替代方法。
J Sep Sci. 2012 Aug;35(15):1906-13. doi: 10.1002/jssc.201101121.
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Application of new primer-enzyme combinations to terminal restriction fragment length polymorphism profiling of bacterial populations in human feces.新型引物 - 酶组合在人粪便细菌群体末端限制性片段长度多态性分析中的应用
Appl Environ Microbiol. 2003 Feb;69(2):1251-62. doi: 10.1128/AEM.69.2.1251-1262.2003.