Department of Radiology, Peking University Third Hospital, 49 North Garden Street, Haidian District, Beijing, 100191, China.
Department of Pathology, School of Basic Medical Science, Peking University Third Hospital, Peking University Health Science Center, 38 Xueyuan Road, Haidian District, Beijing, 100191, China.
Mol Imaging Biol. 2019 Aug;21(4):731-739. doi: 10.1007/s11307-018-1295-7.
To investigate the potential of apparent diffusion coefficient (ADC) histogram parameters in epithelial ovarian cancer (EOC) for distinguishing different tumor stages and determining lymph node status and correlations between ADC values and p53 and Ki-67 expression.
Forty-nine EOC patients underwent preoperative magnetic resonance imaging. Staging and lymph node status were determined postoperatively. ADC values were measured using histogram analysis and compared between groups. Relationships between ADCs and Ki-67 and p53 expression were explored.
DC parameters differed significantly between stage I vs II, I vs III, and I vs IV. The parameters were significantly lower in the lymph node-positive group than in the lymph node-negative group, were significantly negatively correlated with Ki-67 labeling index, and were all significantly lower in the mutation-type p53 group than in the wild-type p53 group.
ADC histogram analysis can help discriminate stage I from advanced-stage EOC and predict lymph node metastasis. ADC parameters were correlated with Ki-67 labeling index; the parameters may help indicate p53 expression.
探讨表观扩散系数（ADC）直方图参数在卵巢上皮性癌（EOC）中的应用潜力，以区分不同的肿瘤分期，确定淋巴结状态，并探讨 ADC 值与 p53 和 Ki-67 表达之间的相关性。
49 例 EOC 患者接受了术前磁共振成像检查。术后确定分期和淋巴结状态。使用直方图分析测量 ADC 值，并在组间进行比较。探索 ADC 值与 Ki-67 和 p53 表达之间的关系。
Ⅰ期与Ⅱ期、Ⅰ期与Ⅲ期、Ⅰ期与Ⅳ期之间的 ADC 参数存在显著差异。淋巴结阳性组的参数明显低于淋巴结阴性组，与 Ki-67 标记指数呈显著负相关，且突变型 p53 组的参数均明显低于野生型 p53 组。
ADC 直方图分析有助于区分Ⅰ期和晚期 EOC，并预测淋巴结转移。ADC 参数与 Ki-67 标记指数相关；这些参数可能有助于指示 p53 表达。
