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机构内中重度痴呆患者认知功能的变化过程:来自严重障碍评估量表简版的证据。

Course of Cognitive Functioning in Institutionalized Persons With Moderate to Severe Dementia: Evidence From the Severe Impairment Battery Short Version.

机构信息

1Section Clinical Neuropsychology,Vrije Universiteit Amsterdam,Amsterdam,The Netherlands.

2Department of Psychology,Leiden University,Leiden,the Netherlands.

出版信息

J Int Neuropsychol Soc. 2019 Feb;25(2):204-214. doi: 10.1017/S1355617718000991. Epub 2018 Nov 20.

Abstract

OBJECTIVES

To adequately monitor the course of cognitive functioning in persons with moderate to severe dementia, relevant cognitive tests for the advanced dementia stages are needed. We examined the ability of a test developed for the advanced dementia stages, the Severe Impairment Battery Short version (SIB-S), to measure cognitive change over time. Second, we examined type of memory impairment measured with the SIB-S in different dementia stages.

METHODS

Participants were institutionalized persons with moderate to severe dementia (N = 217). The SIB-S was administered at 6-month intervals during a 2-year period. Dementia severity at baseline was classified according to Global Deterioration Scale criteria. We used mixed models to evaluate the course of SIB-S total and domain scores, and whether dementia stage at baseline affected these courses.

RESULTS

SIB-S total scores declined significantly over time, and the course of decline differed significantly between dementia stages at baseline. Persons with moderately severe dementia declined faster in mean SIB-S total scores than persons with moderate or severe dementia. Between persons with moderate and moderately severe dementia, there was only a difference in the rate of decline of semantic items, but not episodic and non-semantic items.

CONCLUSIONS

Although modest floor and slight ceiling effects were noted in severe and milder cases, respectively, the SIB-S proved to be one of few available adequate measures of cognitive change in institutionalized persons with moderate to severe dementia. (JINS, 2019, 25, 204-214).

摘要

目的

为了充分监测中重度痴呆患者认知功能的变化过程,需要有针对晚期痴呆患者的相关认知测试。我们研究了专为晚期痴呆患者开发的测试,即严重障碍电池简短版(SIB-S),以衡量随时间推移的认知变化能力。其次,我们研究了 SIB-S 所测量的不同痴呆阶段的记忆障碍类型。

方法

参与者为中重度痴呆(N=217)的住院患者。在 2 年期间,每隔 6 个月进行一次 SIB-S 测试。基线时的痴呆严重程度根据全球衰退量表标准进行分类。我们使用混合模型来评估 SIB-S 总分和领域得分的变化情况,以及基线时的痴呆阶段是否会影响这些变化。

结果

SIB-S 总分随时间显著下降,并且基线时的痴呆阶段对下降过程有显著影响。中度至重度痴呆患者的 SIB-S 总分下降速度快于中度或重度痴呆患者。在中度和中度重度痴呆患者之间,只有语义项目的下降率存在差异,但在情节和非语义项目上则没有差异。

结论

尽管在严重和轻度病例中分别注意到适度的下限和轻微的上限效应,但 SIB-S 被证明是评估中度至重度住院痴呆患者认知变化的少数几种适当方法之一。(JINS,2019,25,204-214)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a55/6390392/e8f2dd7b8fdc/S1355617718000991_fig1.jpg

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