Paul B, Menon S S, Vasthare R, Balakrishnan R, Acharya S
Department of Public Health Dentistry,Manipal College of Dental Sciences,Manipal,Mahe,India.
Department of Otorhinolaryngology,Kasturba Medical College,Manipal,Mahe,India.
J Laryngol Otol. 2018 Dec;132(12):1077-1082. doi: 10.1017/S0022215118002049. Epub 2018 Nov 20.
To compare nasal mucociliary clearance in adult non-smokers, cigarette smokers and bidi smokers using the methylene blue dye test.
The study sample consisted of 20 non-smokers, 20 cigarette smokers and 20 bidi smokers (age range, 20-40 years). A single drop of the methylene blue dye was placed at the anterior end of the inferior turbinate of the participants' nasal cavity. The distance travelled by the methylene blue in 15 minutes inside the nasal cavity was measured. Nasal mucociliary clearance of the three groups was compared using the Kruskal Wallis test.
Nasal mucociliary clearance was significantly decreased in bidi smokers as compared to cigarette smokers and non-smokers (p < 0.05). Multivariate analysis revealed a significant association between nasal mucociliary clearance and bidi smoking, number of cigarettes or bidis smoked per day, and pack-years (all p < 0.05).
Nasal mucociliary clearance measurement is a simple and useful index for assessing the effect of smoking on the mucociliary activity of nasal mucosa.
使用亚甲蓝染色试验比较成年非吸烟者、卷烟吸烟者和比迪烟吸烟者的鼻黏膜纤毛清除功能。
研究样本包括20名非吸烟者、20名卷烟吸烟者和20名比迪烟吸烟者（年龄范围20 - 40岁）。在参与者鼻腔下鼻甲前端滴一滴亚甲蓝染料。测量亚甲蓝在鼻腔内15分钟移动的距离。使用Kruskal Wallis检验比较三组的鼻黏膜纤毛清除功能。
与卷烟吸烟者和非吸烟者相比，比迪烟吸烟者的鼻黏膜纤毛清除功能显著降低（p < 0.05）。多变量分析显示，鼻黏膜纤毛清除功能与比迪烟吸烟、每日吸烟支数或比迪烟支数以及吸烟包年数之间存在显著关联（所有p < 0.05）。
鼻黏膜纤毛清除功能测量是评估吸烟对鼻黏膜纤毛活动影响的一种简单且有用的指标。
