Guangxi Key Laboratory of Agricultural Resources Chemistry & Biotechnology, College of Chemistry & Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China.
Nanomedicine (Lond). 2018 Nov;13(22):2901-2916. doi: 10.2217/nnm-2018-0200. Epub 2018 Nov 20.
The development of new and efficient antibacterial agents is urgent to overcome emerging antimicrobial resistance.
MATERIALS & METHODS: Herein, we have presented a new type of 3D antibacterial system to prompt bacteria to contact with the any plane of nanocomposites.
Comparing the antibacterial activity of graphene oxide, reduced graphene oxide and graphene-loaded nanoflower-like nickelous hydroxide (GN/Ni(OH)) nanocomposites; the GN/Ni(OH) showed stronger bactericidal capability toward Gram-negative/-positive bacteria. Moreover, the GN/Ni(OH) with low cytotoxicity can promote it as 'green' antimicrobial agents. And, the GN/Ni(OH) presented long-term stable antibacterial effectiveness after 2-month storage. The antibacterial mechanisms of GN/Ni(OH) were evidenced as the 3D contact and violent damage to the bacterial structure.
The GN/Ni(OH) provides new insights into the antibacterial properties of 3D nanocomposites for effectively fighting pathogen threats in biomedicine and public health.
为了克服新出现的抗菌药物耐药性，开发新的、有效的抗菌剂迫在眉睫。
本文提出了一种新型的 3D 抗菌系统，以促使细菌与纳米复合材料的任何平面接触。
比较氧化石墨烯、还原氧化石墨烯和负载纳米花状氢氧化镍（GN/Ni(OH)）纳米复合材料的抗菌活性；GN/Ni(OH)对革兰氏阴性/阳性细菌表现出更强的杀菌能力。此外，具有低细胞毒性的 GN/Ni(OH)可以促进其作为“绿色”抗菌剂。而且，GN/Ni(OH)在经过 2 个月的储存后仍保持长期稳定的抗菌效果。GN/Ni(OH)的抗菌机制被证明是 3D 接触和对细菌结构的剧烈破坏。
GN/Ni(OH)为 3D 纳米复合材料的抗菌性能提供了新的见解，可有效应对生物医学和公共卫生领域中病原体的威胁。
