Emerg Infect Dis. 2018 Dec;24(12):2195-2201. doi: 10.3201/eid2412.172060.
We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000-2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A-C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A-C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.
我们收集了 73 株从 2000 年至 2017 年在芬兰赫尔辛基大学医院（Helsinki, Finland）治疗的患者的血液培养物中分离得到的嗜二氧化碳噬纤维菌（Capnocytophaga canimorsus）分离株。我们通过 PCR 和 Western blot 对这些分离株进行了血清型分型，并尝试将病原体血清型与患者特征相关联。我们的分析结果与先前的研究一致，即 3 种（A-C）噬二氧化碳噬纤维菌血清型导致了大多数（91.8%）人类感染，尽管它们只占在狗中发现的分离株的 7.6%。在我们的研究队列中发生的 3 例死亡同样由这些血清型引起。我们发现了 2 株未定型的分离株，我们将它们指定为血清型 J 和 K。我们没有发现血清型与疾病严重程度、免疫状态、酒精滥用或吸烟状况之间存在关联，但感染非 A-C 血清型的患者中狗咬伤更为常见。需要进一步的研究来确认血清型的毒力，并制定策略来降低人类感染这些细菌的风险。
